Brain injury from neurotrauma, stroke, and other brain diseases can lead to brain secondary injury as well as remote organ injury including lungs, heart, kidney, etc. In all these conditions, the cellular and molecular mechanisms underlying the occurrence and development of brain secondary injury and remote organ injury are expected to be fully elucidated. Recent studies suggested that these mechanisms include immune regulation, chronic inflammatory response, production and deposition of pathological proteins such as extracellular vesicles or DAMPs, blood-brain barrier damage, etc. However, there is still a lack of in-depth mechanistic study in most fields, which may limit the exploitation of novel therapeutic strategies in the future.
With the development of neuroimaging, bioinformatics, big-data technology, and next-generation sequencing technologies, interdisciplinary joint research has become the mainstream developing trend of neuroscience. For example, single-cell sequencing, transcriptome sequencing, proteome sequencing, and metabolomic profiling provide powerful tools to allow overall investigation on the cellular, molecular and physiology/pathophysiology mechanism underlying the development of brain injury. Neuroscientists need to cooperate with other disciplines and bioinformatics scientists to complete the multi-omics analysis, to obtain more opportunities to develop novel therapeutic strategies for secondary injury. Consequently, researchers should actively break the disciplinary barriers and strengthen communication between clinical and basic medical research.
In this Research Topic, we will focus on studies on but not limited to coagulopathy and immuno-inflammation response and expand the previous understanding of the pathogenesis of brain injury- associated secondary and remote organ injury, thus exploring their precise treatments for clinical application. We welcome basic and clinical studies, as well as bioinformatics studies with experiments verification, and consider all submissions in the form of original research and review articles. This Research Topic focuses on, but is not limited to:
• Mechanisms of the development of secondary injury including coagulopathy, endothelial barrier damage, immuno-inflammatory response after traumatic brain injury, stroke, intracerebral hemorrhage and subarachnoid hemorrhage
• Mechanisms of the development of remote organ injury including acute lung injury, heat, liver and kidney injury after traumatic brain injury, stroke, intracerebral hemorrhage and subarachnoid hemorrhage
• Relationship and mutual influence between brain injury and remote organ injury.
• Mechanisms in the dissemination of local brain inflammation and coagulopathy.
• Clinical biomarkers for diagnosis or outcome prediction associated with brain injury associated secondary injury and remote organ injury.
• Translational research or in-vivo research of novel drug and materials therapy for brain injury associated secondary injury and remote organ injury.
• Identify the common and disease-specific features of coagulopathy and neural immuno-inflammatory response among various brain injuries.
• Review of recent research advances on pathogenesis, clinical diagnosis, and treatment of brain injury associated secondary and remote organ injury.
Brain injury from neurotrauma, stroke, and other brain diseases can lead to brain secondary injury as well as remote organ injury including lungs, heart, kidney, etc. In all these conditions, the cellular and molecular mechanisms underlying the occurrence and development of brain secondary injury and remote organ injury are expected to be fully elucidated. Recent studies suggested that these mechanisms include immune regulation, chronic inflammatory response, production and deposition of pathological proteins such as extracellular vesicles or DAMPs, blood-brain barrier damage, etc. However, there is still a lack of in-depth mechanistic study in most fields, which may limit the exploitation of novel therapeutic strategies in the future.
With the development of neuroimaging, bioinformatics, big-data technology, and next-generation sequencing technologies, interdisciplinary joint research has become the mainstream developing trend of neuroscience. For example, single-cell sequencing, transcriptome sequencing, proteome sequencing, and metabolomic profiling provide powerful tools to allow overall investigation on the cellular, molecular and physiology/pathophysiology mechanism underlying the development of brain injury. Neuroscientists need to cooperate with other disciplines and bioinformatics scientists to complete the multi-omics analysis, to obtain more opportunities to develop novel therapeutic strategies for secondary injury. Consequently, researchers should actively break the disciplinary barriers and strengthen communication between clinical and basic medical research.
In this Research Topic, we will focus on studies on but not limited to coagulopathy and immuno-inflammation response and expand the previous understanding of the pathogenesis of brain injury- associated secondary and remote organ injury, thus exploring their precise treatments for clinical application. We welcome basic and clinical studies, as well as bioinformatics studies with experiments verification, and consider all submissions in the form of original research and review articles. This Research Topic focuses on, but is not limited to:
• Mechanisms of the development of secondary injury including coagulopathy, endothelial barrier damage, immuno-inflammatory response after traumatic brain injury, stroke, intracerebral hemorrhage and subarachnoid hemorrhage
• Mechanisms of the development of remote organ injury including acute lung injury, heat, liver and kidney injury after traumatic brain injury, stroke, intracerebral hemorrhage and subarachnoid hemorrhage
• Relationship and mutual influence between brain injury and remote organ injury.
• Mechanisms in the dissemination of local brain inflammation and coagulopathy.
• Clinical biomarkers for diagnosis or outcome prediction associated with brain injury associated secondary injury and remote organ injury.
• Translational research or in-vivo research of novel drug and materials therapy for brain injury associated secondary injury and remote organ injury.
• Identify the common and disease-specific features of coagulopathy and neural immuno-inflammatory response among various brain injuries.
• Review of recent research advances on pathogenesis, clinical diagnosis, and treatment of brain injury associated secondary and remote organ injury.
