In the recent years, growing interest is rising in osteoporosis and sarcopenia coexistence that has been defined osteosarcopenia, and might negatively affect the risk of physical impairment and disability, resulting in a crucial burden on both assistance and sanitary costs. In this context, recent research highlighted that bone and muscle share multilevel interactions and several shared risk factors might promote sarcopenia and osteoporosis.
Considering the functional, embryological, and biochemical linkages between bone and muscle tissues, growing literature is now focusing on the bone-muscle crosstalk that might be a key target for a precise approach to fragility fractures.
Secondary osteoporosis is generally associated with a specific etiology; thus, a precise identification of the disease promoting bone loss and skeletal fragility is crucial for a specific therapeutic approach. Although the implication of these disorders has been deeply studied in bone health, there is still a large gap of knowledge about the association of muscle wasting in these diseases. Nevertheless, a comprehensive approach targeting both these tissues might have intriguing implications for functional outcomes and physical performance.
In light of these considerations, effective patient-tailored strategies to overcome these issues are needed in order to integrate an evidence-based approach in the long terms management of risk of fractures in patients with secondary osteoporosis.
Therefore, the aim of this special issue is to provide a broad overview about the evidence supporting a comprehensive approach to the risk of fractures, to guide future research in creating precise and specific interventions integrating comprehensive musculoskeletal health management in patients with secondary osteoporosis.
We invite you to contribute to this article collection about the relationship between bone and muscle tissues in:
- Glucocorticoid induced osteoporosis
- Hypogonadism
- Diabetes
- Inflammatory and rheumatic disorders
- Eating disorders
- Hematologic disorders
- Renal disorders
- Drug-induced osteoporosis
In the recent years, growing interest is rising in osteoporosis and sarcopenia coexistence that has been defined osteosarcopenia, and might negatively affect the risk of physical impairment and disability, resulting in a crucial burden on both assistance and sanitary costs. In this context, recent research highlighted that bone and muscle share multilevel interactions and several shared risk factors might promote sarcopenia and osteoporosis.
Considering the functional, embryological, and biochemical linkages between bone and muscle tissues, growing literature is now focusing on the bone-muscle crosstalk that might be a key target for a precise approach to fragility fractures.
Secondary osteoporosis is generally associated with a specific etiology; thus, a precise identification of the disease promoting bone loss and skeletal fragility is crucial for a specific therapeutic approach. Although the implication of these disorders has been deeply studied in bone health, there is still a large gap of knowledge about the association of muscle wasting in these diseases. Nevertheless, a comprehensive approach targeting both these tissues might have intriguing implications for functional outcomes and physical performance.
In light of these considerations, effective patient-tailored strategies to overcome these issues are needed in order to integrate an evidence-based approach in the long terms management of risk of fractures in patients with secondary osteoporosis.
Therefore, the aim of this special issue is to provide a broad overview about the evidence supporting a comprehensive approach to the risk of fractures, to guide future research in creating precise and specific interventions integrating comprehensive musculoskeletal health management in patients with secondary osteoporosis.
We invite you to contribute to this article collection about the relationship between bone and muscle tissues in:
- Glucocorticoid induced osteoporosis
- Hypogonadism
- Diabetes
- Inflammatory and rheumatic disorders
- Eating disorders
- Hematologic disorders
- Renal disorders
- Drug-induced osteoporosis
