About this Research Topic
As mentioned above, it is necessary to identify changes at each hierarchical level phenotypes of risk gene mutations for ASD. Furthermore, genetic variants that show a common phenotype somewhere in the hierarchy should be grouped as ASD risk genes with a common biological basis, and therapeutics should be developed for the ASD patient population with those in the same group. In addition, as genes to be treated, genes that are suggested to be associated with cognitive and behavioral phenotypes measured with a common index from rodents to humans are considered desirable. One such example is CNTN5, which is associated with the auditory abnormalities of ASD. This symptom is detectable by ABR and other tests that can be tried on rodents and humans alike. The goals of this Research Topic are to gather knowledge on recent research on ASD risk genes’ effects on each hierarchical level phenotype, to clarify the neurodevelopmental effects of ASD risk gene mutations, and to identify novel therapeutic drug candidates that ameliorate these changes.
This Research Topic article collection welcomes any types of manuscripts supported by Frontiers in Neurology, pertaining but not limited to the following themes:
- Identifying for ASD risk gene mutations
- Functional analysis of ASD risk gene mutations at the protein level
- Functional analysis of ASD risk gene mutations at the cellular level
- Functional analysis of ASD risk gene mutations at the brain region level
- Functional analysis of ASD risk gene mutations at the brain circuit level
- Functional analysis of ASD risk gene mutations at the individual cognition and behavior level
Keywords: Autism Spectrum Disorder, ASD, functional analysis, risk gene mutations, high content analysis, autism risk genes, phenotype
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.