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About this Research Topic

Manuscript Submission Deadline 10 May 2023

Neurotrauma, mainly refers to traumatic brain injury (TBI), peripheral nerve injury (PNI) or spinal cord injury (SCI), which is a major public health issue worldwide. It is still considered incurable due to its complicated pathophysiological mechanisms and lifelong neurological deficits. In order to generate more solid and beneficial clinical trials, scientists have been striving to achieve breakthroughs through a variety of approaches, including postinjury microenvironment, neuropathic pain, neural regeneration (referring to molecules including enzymes, receptors, structural proteins, etc.), and accordingly therapeutic interventions. This research topic aims to elucidate the potential pathophysiological mechanism of neurotrauma and molecular mechanisms of neurogenesis, and to search for new neurotrauma biomarkers as indicators of treatment effectiveness. In addition, we also aim to explore new methods, tools and any strategies to facilitate nerve repair and improve neurological function after neurotrauma.

All Original Research and Review articles that focus on, but are not limited to, the topics mentioned below are welcome:

- Postinjury microenvironment changes, covering BBB(BSCB) disruption, neuroinflammation, angiogenesis, and cellular survival. Signaling pathways, molecular proteins and genes involved in the regulation of microenvironments are also of interest in this topic

- The molecular mechanisms of neuropathic pain related to neuronal hyperexcitability, glutamate cytotoxicity, or chemokine release.

- The potential mechanisms of neural regeneration due to axonal regrowth, remyelination, circuit rewiring, endogenous recruit or other regulations.

- Therapeutic methods includes molecules, cell transplantation, non-cellular structure organisms, gene therapies, and rehabilitative interventions.

- Finding a novel material which can be applied as a tool for new drug delivery in terms of neurotrauma treatments and repair.

- The mechanisms of neural plasticity after brain, peripheral nerve injury and spinal cord injury.

- Any intervention and the interesting research that can contribute to nerve repair after neurotrauma.

-To investigate the importance and effectiveness of epigenetics (lncRNA, microRNA, circRNA etc.) in neurotrauma.

Keywords: Neurotrauma, Peripheral and central nerve injury, Neural regeneration, Therapeutic intervention


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Neurotrauma, mainly refers to traumatic brain injury (TBI), peripheral nerve injury (PNI) or spinal cord injury (SCI), which is a major public health issue worldwide. It is still considered incurable due to its complicated pathophysiological mechanisms and lifelong neurological deficits. In order to generate more solid and beneficial clinical trials, scientists have been striving to achieve breakthroughs through a variety of approaches, including postinjury microenvironment, neuropathic pain, neural regeneration (referring to molecules including enzymes, receptors, structural proteins, etc.), and accordingly therapeutic interventions. This research topic aims to elucidate the potential pathophysiological mechanism of neurotrauma and molecular mechanisms of neurogenesis, and to search for new neurotrauma biomarkers as indicators of treatment effectiveness. In addition, we also aim to explore new methods, tools and any strategies to facilitate nerve repair and improve neurological function after neurotrauma.

All Original Research and Review articles that focus on, but are not limited to, the topics mentioned below are welcome:

- Postinjury microenvironment changes, covering BBB(BSCB) disruption, neuroinflammation, angiogenesis, and cellular survival. Signaling pathways, molecular proteins and genes involved in the regulation of microenvironments are also of interest in this topic

- The molecular mechanisms of neuropathic pain related to neuronal hyperexcitability, glutamate cytotoxicity, or chemokine release.

- The potential mechanisms of neural regeneration due to axonal regrowth, remyelination, circuit rewiring, endogenous recruit or other regulations.

- Therapeutic methods includes molecules, cell transplantation, non-cellular structure organisms, gene therapies, and rehabilitative interventions.

- Finding a novel material which can be applied as a tool for new drug delivery in terms of neurotrauma treatments and repair.

- The mechanisms of neural plasticity after brain, peripheral nerve injury and spinal cord injury.

- Any intervention and the interesting research that can contribute to nerve repair after neurotrauma.

-To investigate the importance and effectiveness of epigenetics (lncRNA, microRNA, circRNA etc.) in neurotrauma.

Keywords: Neurotrauma, Peripheral and central nerve injury, Neural regeneration, Therapeutic intervention


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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