Heart and kidney transplant graft survival is suboptimal, with an average half-life of approximately 10 years. T-cells play a crucial role in graft rejection. Following transplantation, antigen recognition of allo-peptides and HLA molecules leads to the activation of donor-reactive T-cells, which underlie potential T-cell-mediated rejection (TCMR) and can promote donor-specific antibody (DSA) formation. T-cell-targeting immunosuppressive therapies currently used in transplant recipients exert their effect on all T cells. The characteristics and the dynamics of T-cell alloimmune responses remain largely undefined, thus hindering our ability to target them selectively.
The advent of single-cell technologies and T-cell receptor (TCR) sequencing has constituted an inflection point in our ability to probe and monitor alloimmune responses. However, these come with the challenge of extracting relevant biological insight from the large datasets generated. Devising novel mechanistic mathematical and statistical modeling approaches is a promising strategy to address this unmet need.
In this Research Topic, we welcome the submission of Original Research, Methods, Reviews, Mini-Reviews, and Perspective articles that cover theoretical or computational approaches, alone or combined with experiments, to study alloimmune T-cell responses, including:
1. Characterization of the dynamics of alloimmune response in peripheral blood and other compartments.
2. Novel mathematical and statistical modeling approaches to quantify main contributing factors in T-cell response, but also generate new insights combining data with models.
3. Changes in TCR repertoires in transplant recipients and murine transplantation models.
4. Protocols and in vitro assays to identify and quantify donor-reactive T-cell responses.
5. Comprehensive immune phenotyping of the donor-reactive T-cell subsets.
Heart and kidney transplant graft survival is suboptimal, with an average half-life of approximately 10 years. T-cells play a crucial role in graft rejection. Following transplantation, antigen recognition of allo-peptides and HLA molecules leads to the activation of donor-reactive T-cells, which underlie potential T-cell-mediated rejection (TCMR) and can promote donor-specific antibody (DSA) formation. T-cell-targeting immunosuppressive therapies currently used in transplant recipients exert their effect on all T cells. The characteristics and the dynamics of T-cell alloimmune responses remain largely undefined, thus hindering our ability to target them selectively.
The advent of single-cell technologies and T-cell receptor (TCR) sequencing has constituted an inflection point in our ability to probe and monitor alloimmune responses. However, these come with the challenge of extracting relevant biological insight from the large datasets generated. Devising novel mechanistic mathematical and statistical modeling approaches is a promising strategy to address this unmet need.
In this Research Topic, we welcome the submission of Original Research, Methods, Reviews, Mini-Reviews, and Perspective articles that cover theoretical or computational approaches, alone or combined with experiments, to study alloimmune T-cell responses, including:
1. Characterization of the dynamics of alloimmune response in peripheral blood and other compartments.
2. Novel mathematical and statistical modeling approaches to quantify main contributing factors in T-cell response, but also generate new insights combining data with models.
3. Changes in TCR repertoires in transplant recipients and murine transplantation models.
4. Protocols and in vitro assays to identify and quantify donor-reactive T-cell responses.
5. Comprehensive immune phenotyping of the donor-reactive T-cell subsets.
