Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) is a common otological emergency defined as hearing loss of at least 30 dB in three sequential frequencies within 72 h. Many etiologies of ISSNHL have been proposed, including viral infection, vascular occlusion, immune-mediated mechanisms, etc. However, the exact pathophysiology still needs to be elucidated. The equivocal etiologies lead to many empirical treatment protocols. There still needs to be a consensus on the best treatment option for ISSNHL because of an unclear etiology. Although the most frequently used therapy is the administration of steroids, other various empirical treatments also have been applied by some doctors in many countries to improve blood circulation and to increase oxygen concentration in the inner ear to further improve the therapeutic effect of ISSNHL, including hyperbaric oxygen therapy, vasodilators, plasma expanders, and anticoagulant agents, etc. However, according to the current treatment regimen, many patients still have poor efficacy.
The topic of this study is the etiological mechanisms and treatments of ISSNHL. This Research Topic aims to gather recent findings that elaborate on the advanced etiological mechanisms and treatments of ISSNHL. We welcome both human studies and animal studies. We encourage studies making use of molecular biology. We welcome Original Research, Systematic Reviews, Literature Reviews, and Mini Review including but not limited to the following:
- Cohort studies or cross-sectional studies of ISSNHL
- Potential hypothesis of etiological mechanisms of ISSNHL
- Application of new technologies and methods in the study of ISSNHL
- Intervention studies of ISSNHL, including hyperbaric oxygen therapy, vasodilators, plasma expanders, anticoagulant agents, Chinese herbal medicine, etc.
- Simulated or real animal experimental studies of ISSNHL, including pathophysiological changes of the inner ear, hearing, proteomic, and intervention studies
- A follow-up study of hearing and brain function changes in ISSNHL
Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) is a common otological emergency defined as hearing loss of at least 30 dB in three sequential frequencies within 72 h. Many etiologies of ISSNHL have been proposed, including viral infection, vascular occlusion, immune-mediated mechanisms, etc. However, the exact pathophysiology still needs to be elucidated. The equivocal etiologies lead to many empirical treatment protocols. There still needs to be a consensus on the best treatment option for ISSNHL because of an unclear etiology. Although the most frequently used therapy is the administration of steroids, other various empirical treatments also have been applied by some doctors in many countries to improve blood circulation and to increase oxygen concentration in the inner ear to further improve the therapeutic effect of ISSNHL, including hyperbaric oxygen therapy, vasodilators, plasma expanders, and anticoagulant agents, etc. However, according to the current treatment regimen, many patients still have poor efficacy.
The topic of this study is the etiological mechanisms and treatments of ISSNHL. This Research Topic aims to gather recent findings that elaborate on the advanced etiological mechanisms and treatments of ISSNHL. We welcome both human studies and animal studies. We encourage studies making use of molecular biology. We welcome Original Research, Systematic Reviews, Literature Reviews, and Mini Review including but not limited to the following:
- Cohort studies or cross-sectional studies of ISSNHL
- Potential hypothesis of etiological mechanisms of ISSNHL
- Application of new technologies and methods in the study of ISSNHL
- Intervention studies of ISSNHL, including hyperbaric oxygen therapy, vasodilators, plasma expanders, anticoagulant agents, Chinese herbal medicine, etc.
- Simulated or real animal experimental studies of ISSNHL, including pathophysiological changes of the inner ear, hearing, proteomic, and intervention studies
- A follow-up study of hearing and brain function changes in ISSNHL