Osteoporosis is a bone disease characterized by low bone mineral density, as well as compromised bone quality and strength, leading to increased risk of fragility fractures. Both women and men are at risk for sustaining non-traumatic fractures as a result of age-related decreases in bone density and strength and these fractures are associated with increased disability and mortality. While genetics and dietary factors are important contributors to skeletal health, mechanical loading through weight-bearing exercise and resistance exercise is critical for the maintenance of a healthy skeleton throughout the lifespan. In addition to weight-bearing and resistance exercise, there are novel bone loading techniques, such as whole-body vibration, that have been shown to provide a sufficient stimulus to alter bone metabolism. It is important to determine characteristics of exercise interventions that would be most beneficial to bone health.
The aim of this research topic is to solicit original research papers that address the knowledge gap regarding bone-loading characteristics, such as mode, intensity, frequency, duration and volume of exercise, utilizing either animal and/or human models. Advances in techniques for assessment of bone density, geometry, and quality provide opportunities to expand the knowledge on the effects of mechanical loading on the skeleton. Measurement of bone markers and bone regulatory factors in serum and in bone tissue have the potential to add important information about how bone metabolism is altered by different types of exercise.
This research topic will focus on the following areas:
- Mechanisms of mechanical loading effects on the skeleton assessed by bone biomarkers, microRNAs, DXA, pQCT, HR-pQCT, cortical bone mapping, etc. using animal models.
- Human studies on the effects of different types of mechanical loading (e.g., resistance exercise, weight bearing, whole-body vibration, blood flow restriction, etc.) on bone density, geometry and quality and biomarkers of bone metabolism.
- Human studies directly comparing exercise protocols of differing intensity and duration on bone density, geometry, and quality and biomarkers of bone metabolism.
Osteoporosis is a bone disease characterized by low bone mineral density, as well as compromised bone quality and strength, leading to increased risk of fragility fractures. Both women and men are at risk for sustaining non-traumatic fractures as a result of age-related decreases in bone density and strength and these fractures are associated with increased disability and mortality. While genetics and dietary factors are important contributors to skeletal health, mechanical loading through weight-bearing exercise and resistance exercise is critical for the maintenance of a healthy skeleton throughout the lifespan. In addition to weight-bearing and resistance exercise, there are novel bone loading techniques, such as whole-body vibration, that have been shown to provide a sufficient stimulus to alter bone metabolism. It is important to determine characteristics of exercise interventions that would be most beneficial to bone health.
The aim of this research topic is to solicit original research papers that address the knowledge gap regarding bone-loading characteristics, such as mode, intensity, frequency, duration and volume of exercise, utilizing either animal and/or human models. Advances in techniques for assessment of bone density, geometry, and quality provide opportunities to expand the knowledge on the effects of mechanical loading on the skeleton. Measurement of bone markers and bone regulatory factors in serum and in bone tissue have the potential to add important information about how bone metabolism is altered by different types of exercise.
This research topic will focus on the following areas:
- Mechanisms of mechanical loading effects on the skeleton assessed by bone biomarkers, microRNAs, DXA, pQCT, HR-pQCT, cortical bone mapping, etc. using animal models.
- Human studies on the effects of different types of mechanical loading (e.g., resistance exercise, weight bearing, whole-body vibration, blood flow restriction, etc.) on bone density, geometry and quality and biomarkers of bone metabolism.
- Human studies directly comparing exercise protocols of differing intensity and duration on bone density, geometry, and quality and biomarkers of bone metabolism.