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Challenging the Functional Connectivity Disruption in Neurodegenerative Diseases: New Therapeutic Perspectives through Non-Invasive Neuromodulation and Cutting-Edge Technologies

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It is undeniable that among the Neurosciences, the rehabilitation field is increasingly focused on understanding how to efficiently revert the effects that acute (i.e., stroke or traumatic brain injury) or chronic (i.e., neurodegenerative diseases) insults play either on small or large-scale networks, ...

It is undeniable that among the Neurosciences, the rehabilitation field is increasingly focused on understanding how to efficiently revert the effects that acute (i.e., stroke or traumatic brain injury) or chronic (i.e., neurodegenerative diseases) insults play either on small or large-scale networks, encompassing motor, sensory and cognitive domains. The link between the disrupted neuronal pulse generators and their effectors is being re-shaped through a wide scenario that embraces biorobotics, robot-aided rehabilitation, non-invasive neurostimulation, nanoprosthetics and neuroengineering. For the past decade and at an amazing speed, large investments and efforts allowed enthusiastic and only apparently heterogeneous researchers to borrow theories from neurophysiology, pharmacology, physics and quantum mechanics in order to generate together highly sophisticated tools that restore , resemble or even substitute the basic biological architecture. The idea of actually reverting weakened functions and/or replacing the faulty parts either of the human body or the central and peripheral nervous system is becoming a new reality, opening a fascinating era in this field.

This Research Topic welcomes researchers who belong to the above realm at any level, from the theory to the bedside of patients. It is important that the papers illustrate the workflow for the implementation of the whole process, focusing on the steps where they achieved most, up to the final stage. Successful projects and collaborative networks are highly encouraged in order to foster further developments.


Keywords: rehabilitation, neurodegeneration, non-invasive techniques, tDCS, biorobotics, neurostimulation, translational research, nanotechnology, quantum mechanics, nanoprosthetics, neurophysiology, functional connectivity, implantable devices, neuroprostheses


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