About this Research Topic
This Research Topic seeks to provide an overview of nanotargeted radiopharmaceuticals, up-to-date research, current status of applications, advantages, limitations and future prospects and challenges. Nanoparticles are sufficiently small to diffuse through the endothelial cell layers and interact with the cell structures of various tissues, but also large enough to transport high payloads of one or several therapeutic or diagnostic agents (i.e. radionuclides). They can be engineered to have different sizes, morphologies, chemical compositions, surface chemical characteristics, and hollow or solid structures and have tunable physical and biologic properties. Most of the organic and inorganic nanocarriers are notably amenable to chemical conjugation for radiolabeling through either direct methods or chelation. Research on the combination of different radionuclides or radiopharmaceuticals with passively or actively targeted nanoparticles offers the possibility to increase personalized diagnostic efficacy and radiotherapeutic index. Nevertheless, further efforts and challenges in preclinical and clinical efficiency and toxicity studies are essential to translate those advanced new technologies to the clinical applications for the healthcare benefit of the patients.
This Research Topic welcomes submissions dealing with recent progresses in the field of nanomedicine and radiopharmaceuticals, with new approaches to the design and formulation of innovative radiolabeled nanoconstructs and their applications. Original research, as well as review articles, on the use of nanomaterials for receptor-specific tumor targeting, radionuclide encapsulation, multimodality imaging, and/or multifunctional approach for cancer theranostics, as well as radiotoxicology/nanotoxicology, clinical research and regulatory issues are encouraged.
Keywords: Drug delivery, molecular imaging, multimodality, nanomedicine, nuclear medicine, radiolabeled nanomaterials, radionuclide therapy, radiopharmaceuticals, theranostics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.