About this Research Topic
Post-acute sequelae of SARS-CoV-2 infection (PASC) may involve multiple systems. Significant symptoms include “burden-fatigue”, "brain fog", exercise oversensitivity, post-exertional malaise, anxiety, sleep difficulties, and depression. PACS may become chronic and mimic myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A recent hypothesis posits that a chronic state of multisystemic disequilibrium causes ME/CFS and PASC. The hypothesis suggests that there are multiple interconnections between the autonomic system, central nervous system, and brain stem. Up to now, this theoretical approach remains speculative, however, both in PASC and in ME/CFS, there are hemodynamic, cardiovascular, and autonomic abnormalities, for example, postural orthostatic tachycardia syndrome and orthostatic hypotension.
In neuro-PASC, a direct or indirect invasion of the virus into the brain may cause immune dysregulation, hormonal disorders, elevated cytokine levels due to immune reaction and chronic inflammation, direct tissue injury, or even persistent low-grade infection. For this reason, in this second volume of the Research topic, we solicit new submissions on neurologic, cardiac, and autonomic dysfunction in patients with PASC.
For this Research Topic Vol 2, we welcome submissions of Original Research, Reviews, and Meta-Analyses.
Visit Volume I of this Research Topic.
Keywords: COVID-19, cardiovascular diseases, Autonomic Nervous System, cardiac innnervation, cardiorespiratory nuclei, sudden death, vaccinations
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