Research Topic

Endocannabinoid regulation of dopamine processing in the brain

  • Submission closed.

About this Research Topic

Compromised dopaminergic neurotransmission results in a wide variety of pathophysiological states such as schizophrenia, Parkinson’s disease and drug addiction. The endogenous cannabinoid system has been clearly implicated in each of these debilitating conditions, but a link between maladaptive dopamine ...

Compromised dopaminergic neurotransmission results in a wide variety of pathophysiological states such as schizophrenia, Parkinson’s disease and drug addiction. The endogenous cannabinoid system has been clearly implicated in each of these debilitating conditions, but a link between maladaptive dopamine dynamics and signaling at cannabinoid receptors is still unclear. It is therefore of paramount importance to examine maladaptive dopamine activity and to what extent this involves changes in the way endogenous cannabinoid tone modulates dopamine dynamics under normal and pathological conditions. The topic will start by a sophisticated anatomical study of time-dependent alterations of CB1 receptor expression during development, specifically in corticostriatal circuits (Van Waes, Siman, Tseng and Steiner). This will then be followed by an exploration of the role of new players (i.e., adenosine) in the tight relationship between endocannabinoid signaling and D2 receptor activation in the production of long-term synaptic plasticity in the dorsal striatum (Mathur and Lovinger). Next, we will examine reward processing in the ventral striatum in a review, which will highlight how dopaminergic neurons in the VTA can regulate their afferent input via activation of CB1 receptors following the generation of endocannabinoids (2AG principally). The authors postulate that such exquisite modulation is critical in the production of normal motivated behaviors (Melis, Muntoni and Pistis). This hypothesis is explored in a behavioral setting in report showing that activation of CB1 receptors potentiates the hedonic effects of a highly palatable tastant, through a potentiation of dopamine release in the nucleus accumbens. Importantly it is shown that CB1 receptor stimulation is devoid of effects when an aversive tastant is utilized suggesting a primary role of CB1 receptor activation on dopaminergic information processing directed towards the detection and valuation of rewards (De Luca, Solinas, Bimpisidis, Goldberg and Di Chiara).


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top