Autoimmune disease has become the third largest chronic disease in the world, except cardiovascular disease and cancer. Autoimmune diseases are characterized by an exaggerated immune response leading to damage and dysfunction of specific or multiple organs and tissues. Immune cells are activated and lose the ability to recognize "self" and "non-self" and migrate to specific tissues and organs leading to autoimmune diseases. It is important to study how immune cells recruit into specific organs and what components regulate immune cell trafficking.
Integrins, chemokines, adhesion molecules, and skeleton proteins of immune cells were critically involved in cell migration. Inflammation, biological rhythm, metabolism, and gene mutant could regulate the expression and localization of these molecules on monocytes, macrophages, T lymphocytes, or B lymphocytes to influence their adhesion, intravascular crawling, migration, and the formation of immune synapses between immune cells or with target cells to mediate immune response and tissue damage.
Many advanced technologies and methods have been used to study immune cell locomotion and trafficking, such as microfluidics, intravital microscopy, single-cell detection and analysis technology, in vivo flow cytometry, organelles, etc. These research methods provide functional or visual evidence to reveal the mechanism of immune cell recruitment. Targeting the recruitment of immune cells could intervene and treat autoimmune diseases.
The goal of this Research Topic is to provide a forum to advance research on the mechanism of immune cell migration in autoimmune diseases and to explore the novel therapeutic targets for these diseases by advanced technologies and methods, which would have beneficial impacts on the studying of autoimmune diseases.
This Research Topic aims to collect studies regarding the mechanisms regulating immune cell locomotion and trafficking in autoimmune diseases. The diseases include but are not limited to autoimmune uveitis, autoimmune hepatitis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, Sjögren's syndrome, and so on. This topic also collects the studies that use advanced technologies and methods including but not limited to in vivo flow cytometry, two-photon, and single-cell RNA sequencing, to study immune cell migration. We welcome the submission of Review, Original Research, Perspective, Clinical Trial, and Case Report articles covering, but not limited to, the following subtopics:
(1) Regulatory mechanism in immune cell activation, migration, and recruitment in autoimmune diseases.
(2) Role of adhesion molecules, integrins, and chemokines in the development of autoimmune diseases.
(3) Therapeutic targeting of adhesion molecules, integrins, and chemokines in autoimmune diseases.
(4) Advanced techniques used to study the migration and recruitment of immune cells in autoimmune diseases.
Autoimmune disease has become the third largest chronic disease in the world, except cardiovascular disease and cancer. Autoimmune diseases are characterized by an exaggerated immune response leading to damage and dysfunction of specific or multiple organs and tissues. Immune cells are activated and lose the ability to recognize "self" and "non-self" and migrate to specific tissues and organs leading to autoimmune diseases. It is important to study how immune cells recruit into specific organs and what components regulate immune cell trafficking.
Integrins, chemokines, adhesion molecules, and skeleton proteins of immune cells were critically involved in cell migration. Inflammation, biological rhythm, metabolism, and gene mutant could regulate the expression and localization of these molecules on monocytes, macrophages, T lymphocytes, or B lymphocytes to influence their adhesion, intravascular crawling, migration, and the formation of immune synapses between immune cells or with target cells to mediate immune response and tissue damage.
Many advanced technologies and methods have been used to study immune cell locomotion and trafficking, such as microfluidics, intravital microscopy, single-cell detection and analysis technology, in vivo flow cytometry, organelles, etc. These research methods provide functional or visual evidence to reveal the mechanism of immune cell recruitment. Targeting the recruitment of immune cells could intervene and treat autoimmune diseases.
The goal of this Research Topic is to provide a forum to advance research on the mechanism of immune cell migration in autoimmune diseases and to explore the novel therapeutic targets for these diseases by advanced technologies and methods, which would have beneficial impacts on the studying of autoimmune diseases.
This Research Topic aims to collect studies regarding the mechanisms regulating immune cell locomotion and trafficking in autoimmune diseases. The diseases include but are not limited to autoimmune uveitis, autoimmune hepatitis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, Sjögren's syndrome, and so on. This topic also collects the studies that use advanced technologies and methods including but not limited to in vivo flow cytometry, two-photon, and single-cell RNA sequencing, to study immune cell migration. We welcome the submission of Review, Original Research, Perspective, Clinical Trial, and Case Report articles covering, but not limited to, the following subtopics:
(1) Regulatory mechanism in immune cell activation, migration, and recruitment in autoimmune diseases.
(2) Role of adhesion molecules, integrins, and chemokines in the development of autoimmune diseases.
(3) Therapeutic targeting of adhesion molecules, integrins, and chemokines in autoimmune diseases.
(4) Advanced techniques used to study the migration and recruitment of immune cells in autoimmune diseases.
