About this Research Topic
1. Genetic control of central 5-HT development.
2. Role of central 5-HT in the development of brain circuits.
3. 5-HT regulation of adult neurogenesis and its implications in learning and memory.
4. Reprogramming human ES cells into 5-HT neurons.
5. Dissecting the direct inputs to 5-HT neurons with transsynaptic viral tracing technique.
6. Roles and circuit mechanisms of the central 5-HT system in reward processing and drug abuse.
7. Roles and mechanism of the central 5-HT system in behavioral homeostasis, including thermal regulation, food intake, and sociosexual behaviors.
8. The relationship between central 5-HT levels and the etiology and treatment of depression. Recent data challenge the monoamine hypothesis in depression, and new model has been proposed. That is, intact 5-HT system is required for the antidepressant effects or first-line antidepressant drugs (specific serotonin reuptake inhibitor), but central 5-HT deficit is not sufficient to induce depression. This is a critical issue, because it directly points or closely relates to direction of developing new drugs in treating depression.
Keywords: serotonin, development, circuit, behavior, psychiatric disorders
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