Macrophages play a central role in developing and progressing several metabolic and cardiovascular diseases, including diabetes, hypertension, atherosclerosis, and heart disease. Macrophages also play a role in activating and regulating immune responses and in tissue repair and remodeling. Macrophages are usually the first immune cells to encounter invading pathogens. Once they catch pathogens, they immediately activate their defense arsenal, recruit other immune cells and initiate the adaptive immune response. At the same time, alternately activated macrophages establish an immunosuppressive environment to inhibit the function of other cell types.
Recent research has highlighted the potential therapeutic use of macrophage-targeted treatments for a variety of inflammatory diseases, including:
? Diabetes: Macrophages are involved in the inflammation and insulin resistance that occurs in diabetes. Recent studies have shown that targeting macrophages with drugs that inhibit specific inflammatory signaling pathways may help improve insulin sensitivity and glucose metabolism.
? Hypertension: Macrophages are involved in the development of hypertension, a major risk factor for heart disease. Recent research suggests that targeting macrophages with drugs that inhibit the activity of specific inflammatory signaling pathways may help prevent or treat hypertension. For example, studies have shown that macrophage-specific inhibition of the NADPH oxidase enzyme can help reduce blood pressure in hypertensive rats.
? Atherosclerosis: Macrophages are involved in the development of atherosclerosis, the underlying cause of most heart attacks and strokes. It is suggested that targeting macrophages with drugs that inhibit the activity of specific inflammatory signaling pathways may help prevent or treat this condition.
? Heart disease: Macrophages are involved in the inflammation and fibrosis that occur in the heart during heart disease, and recent studies have shown that targeting macrophages with drugs that inhibit specific inflammatory signaling pathways may help improve outcomes in patients with heart disease.
Therefore, the balance of macrophage activation is crucial to the health of the host. It's worth noting that research in these areas is still ongoing and that more studies are needed to fully understand the role of macrophages in different inflammatory diseases and to develop effective macrophage-targeted therapies.
We welcome the submissions of Reviews, Original research articles, and Clinical trial data covering but not limited to the following subtopics:
(1) Behavior, distribution, function, and outcome of macrophages in the progression of metabolic and cardiovascular diseases.
(2) Origin and differentiation of macrophages in metabolic and cardiovascular diseases.
(3) Functions and biomarkers of specific macrophage subsets.
(4) Molecular regulation mechanism of macrophage function.
(5) Macrophage-specific targeting and delivery tools and their applications in metabolic and cardiovascular diseases.
(6) The development of macrophage fate and function in metabolic and cardiovascular diseases.
(7) We also welcome the clinical study on treating metabolic and cardiovascular diseases based on regulating macrophage migration, polarization, alternative activation, etc.
Macrophages play a central role in developing and progressing several metabolic and cardiovascular diseases, including diabetes, hypertension, atherosclerosis, and heart disease. Macrophages also play a role in activating and regulating immune responses and in tissue repair and remodeling. Macrophages are usually the first immune cells to encounter invading pathogens. Once they catch pathogens, they immediately activate their defense arsenal, recruit other immune cells and initiate the adaptive immune response. At the same time, alternately activated macrophages establish an immunosuppressive environment to inhibit the function of other cell types.
Recent research has highlighted the potential therapeutic use of macrophage-targeted treatments for a variety of inflammatory diseases, including:
? Diabetes: Macrophages are involved in the inflammation and insulin resistance that occurs in diabetes. Recent studies have shown that targeting macrophages with drugs that inhibit specific inflammatory signaling pathways may help improve insulin sensitivity and glucose metabolism.
? Hypertension: Macrophages are involved in the development of hypertension, a major risk factor for heart disease. Recent research suggests that targeting macrophages with drugs that inhibit the activity of specific inflammatory signaling pathways may help prevent or treat hypertension. For example, studies have shown that macrophage-specific inhibition of the NADPH oxidase enzyme can help reduce blood pressure in hypertensive rats.
? Atherosclerosis: Macrophages are involved in the development of atherosclerosis, the underlying cause of most heart attacks and strokes. It is suggested that targeting macrophages with drugs that inhibit the activity of specific inflammatory signaling pathways may help prevent or treat this condition.
? Heart disease: Macrophages are involved in the inflammation and fibrosis that occur in the heart during heart disease, and recent studies have shown that targeting macrophages with drugs that inhibit specific inflammatory signaling pathways may help improve outcomes in patients with heart disease.
Therefore, the balance of macrophage activation is crucial to the health of the host. It's worth noting that research in these areas is still ongoing and that more studies are needed to fully understand the role of macrophages in different inflammatory diseases and to develop effective macrophage-targeted therapies.
We welcome the submissions of Reviews, Original research articles, and Clinical trial data covering but not limited to the following subtopics:
(1) Behavior, distribution, function, and outcome of macrophages in the progression of metabolic and cardiovascular diseases.
(2) Origin and differentiation of macrophages in metabolic and cardiovascular diseases.
(3) Functions and biomarkers of specific macrophage subsets.
(4) Molecular regulation mechanism of macrophage function.
(5) Macrophage-specific targeting and delivery tools and their applications in metabolic and cardiovascular diseases.
(6) The development of macrophage fate and function in metabolic and cardiovascular diseases.
(7) We also welcome the clinical study on treating metabolic and cardiovascular diseases based on regulating macrophage migration, polarization, alternative activation, etc.
