Skip to main content

About this Research Topic

Submission closed.

For synaptic transmission, synaptic vesicles undergo rapid turnover – they are consumed for the transmitter release and subsequently recovered from the plasma membrane via endocytosis. During this rapid turnover, however, synaptic vesicles must maintain their molecular and lipid constituents for their proper ...

For synaptic transmission, synaptic vesicles undergo rapid turnover – they are consumed for the transmitter release and subsequently recovered from the plasma membrane via endocytosis. During this rapid turnover, however, synaptic vesicles must maintain their molecular and lipid constituents for their proper functions. Over the last four decades, many experimental approaches and various model systems have been used to study the cellular and molecular mechanisms underlying synaptic vesicle cycle. However, we still lack a complete picture of how this process is mediated. Currently, there are four distinctive models: clathrin-mediated endocytosis, kiss-and-run, bulk endocytosis, and ultrafast endocytosis. The key question in the field is whether there is a unified model for synaptic vesicle recycling or whether specialized mechanisms exist in particular types of synapses or under certain physiological conditions. In addition, the requirement for clathrin and dynamin as pivotal molecules in the process is also still under debate. The purpose of this research topic is to compile both review papers and primary research papers describing the cellular and molecular mechanisms of synaptic vesicle cycle in different model systems. Our goal is to provide neuroscientists an overview of our current understanding of synaptic vesicle cycle.

Keywords: Synaptic vesicle endocytosis, synaptic vesicle recycling, synaptic vesicle cycle


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic Editors

Loading..

Topic Coordinators

Loading..

Recent Articles

Loading..

Articles

Sort by:

Loading..

Authors

Loading..

views

total views views downloads topic views

}
 
Top countries
Top referring sites
Loading..

Share on

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.