About this Research Topic
Limited access to human brain development presents a challenge to understanding mechanisms of human neurodevelopmental disorders. Brain organoids have provided access to some aspects of human brain development that could be dysregulated and contributing to the establishment of neurodevelopmental disorders and subsequent behaviors. However, a key question remains outstanding; how much of adult and age-related brain disorders are foreshadowed in early brain development and can brain organoids reveal this underlying biology? Additionally, are there specific mechanisms, pathways or homeostatic processes that can be perturbed to induce aging-related brain pathologies in brain organoids which typically model processes of early brain development?
This research topic explores the potential of brain organoids to model not only the etiology of brain disorders but also pathogenesis, including neurodegeneration throughout aging and subsequent brain atrophy. We welcome original research articles, reviews, methods, opinions, and letters related to the relevance of and advancements in brain organoid technology to model brain disorders with origins in brain development, like schizophrenia and autism spectrum disorder, and those associated with aging and neurodegeneration, including but not limited to Alzheimer’s disease and Parkinson’s disease. We hope that this topic highlights the advantages, challenges, and future directions of brain organoids in disease modeling and therapeutic development.
Keywords: Brain organoids, brain disorders, neurodegeneration, aging, neurodevelopmental disorders
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