Gulf War Illness (GWI) affects ~30% of the 700,000 veterans who served in the 1991 Gulf War. Veterans with GWI display chronic symptoms such as fatigue, headaches, cognitive dysfunction, difficulty concentrating, musculoskeletal pain, and respiratory, gastrointestinal, and dermatologic complaints. Studies have implied that multiple deployment-related exposures are common etiologies, including pesticides, nerve gas agents, and prophylactic medications (pyridostigmine bromide). GWI is marked by chronic impairments in the central nervous system (CNS), encompassing cognitive deficits, mood alterations, difficulties in concentration, recurring headaches, chronic fatigue, and musculoskeletal pain. These symptoms are distinct features characterizing the pathophysiological condition. Studies in veterans with GWI suggest that these CNS impairments are linked to multiple adverse changes in neurons, glia, and immune cells in the brain. Promising advancements have been achieved in comprehending the underlying mechanisms of brain dysfunction in GWI through recent investigations utilizing animal and human stem cell models. These studies hold the potential to enhance the quality of life for veterans afflicted by GWI. Clinical trials in veterans with GWI have also tested the effectiveness of several drug and behavioral treatment approaches. This Research Topic will publish articles that provide novel insights into the pathophysiology and treatment of brain dysfunction in GWI.
This Research Topic aims to publish original research and review articles that provide novel insights into the pathophysiology and treatment of GWI. Articles describing novel findings from animal prototypes and veterans with GWI on mechanisms underlying its pathophysiology and promising therapeutic approaches for alleviating brain dysfunction in GWI will be considered.
Both original research and review articles on the following areas are desired:
1) Animal models, human stem cell models and clinical studies reporting cellular and molecular changes underlying brain dysfunction in GWI, particularly those describing adverse alterations in the function of neurons, glia, immune cells, and microbiome contributing to brain dysfunction in GWI.
2) Reviews/perspectives on the altered course of brain aging and persistent neuroimmune alterations in veterans with GWI.
3) Results of promising blood and brain biomarker studies, innovative brain imaging studies and high throughput analyses in veterans with GWI predicting early onset of age-related neurodegenerative diseases.
4) Novel findings from preclinical studies that promise to improve brain function in veterans with GWI.
5) Review of ongoing clinical trials and their promise for improving brain function in GWI.
Gulf War Illness (GWI) affects ~30% of the 700,000 veterans who served in the 1991 Gulf War. Veterans with GWI display chronic symptoms such as fatigue, headaches, cognitive dysfunction, difficulty concentrating, musculoskeletal pain, and respiratory, gastrointestinal, and dermatologic complaints. Studies have implied that multiple deployment-related exposures are common etiologies, including pesticides, nerve gas agents, and prophylactic medications (pyridostigmine bromide). GWI is marked by chronic impairments in the central nervous system (CNS), encompassing cognitive deficits, mood alterations, difficulties in concentration, recurring headaches, chronic fatigue, and musculoskeletal pain. These symptoms are distinct features characterizing the pathophysiological condition. Studies in veterans with GWI suggest that these CNS impairments are linked to multiple adverse changes in neurons, glia, and immune cells in the brain. Promising advancements have been achieved in comprehending the underlying mechanisms of brain dysfunction in GWI through recent investigations utilizing animal and human stem cell models. These studies hold the potential to enhance the quality of life for veterans afflicted by GWI. Clinical trials in veterans with GWI have also tested the effectiveness of several drug and behavioral treatment approaches. This Research Topic will publish articles that provide novel insights into the pathophysiology and treatment of brain dysfunction in GWI.
This Research Topic aims to publish original research and review articles that provide novel insights into the pathophysiology and treatment of GWI. Articles describing novel findings from animal prototypes and veterans with GWI on mechanisms underlying its pathophysiology and promising therapeutic approaches for alleviating brain dysfunction in GWI will be considered.
Both original research and review articles on the following areas are desired:
1) Animal models, human stem cell models and clinical studies reporting cellular and molecular changes underlying brain dysfunction in GWI, particularly those describing adverse alterations in the function of neurons, glia, immune cells, and microbiome contributing to brain dysfunction in GWI.
2) Reviews/perspectives on the altered course of brain aging and persistent neuroimmune alterations in veterans with GWI.
3) Results of promising blood and brain biomarker studies, innovative brain imaging studies and high throughput analyses in veterans with GWI predicting early onset of age-related neurodegenerative diseases.
4) Novel findings from preclinical studies that promise to improve brain function in veterans with GWI.
5) Review of ongoing clinical trials and their promise for improving brain function in GWI.