Cellular stress, being considered as any disturbance in cellular physiology, is a fundamental aspect of tissue and body capacity to adapt to the ever changing environment. It also surges as a consequence of tissue injury or invasion of the body by pathogens. Since the immune system was developed to sense and respond to these deleterious processes, it is reasonable to consider that immune cells are capable of sensing and responding to signs of cellular stress. Moreover, cells of the immune system undergo cellular stress during an immune response.

In this Research Topic, we would like to discuss how cellular stress influences the outcome of immune responses. We would like to cover not only how cellular stress can be a fundamental process during immune cell activation and function, but also how cells of the immune system are capable of sensing and being influenced by factors produced by stressed cells.

Review topics should cover, but may not be limited to the following aspects:
Endoplasmic reticulum stress;
Autophagy;
DNA damage response;
Immune cell metabolism; and
Modulation of immune cell function by metabolites.

Keywords: cellular stress, immune response

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.