Hundreds of millions of patients undergo anesthesia for surgery each year, making the adverse effects of anesthesia/surgery a significant public health concern. Among these adverse effects, perioperative neurocognitive disorder (PND) stands out as a critical issue. PNS refers to accelerated neurocognitive decline before and after anesthesia/surgery, including post-operative delirium, deficits in executive function, postoperative memory and cognitive dysfunction, postoperative personality change, sleep disorder, and perioperative stroke. However, the intrinsic mechanism between PND and anesthesia/surgery remains elusive, necessitating further research to identify the strategies to protect brain health during the perioperative period. There are a lot of questions that remain to be solved. For instance, the development of suitable animal models and detective methods for postoperative delirium research is yet to be accomplished. Additionally, there is a need to optimize pre-operative screen methods for susceptible populations of PND. Furthermore, more comprehensive investigations are required to understand the roles of neuroinflammation, neurodegeneration, glial cells, as well as the altered activity of neural circuits in PND.
In this Research Topic, we aim to gather the latest advances in perioperative neurocognitive disorders and explore the potential strategies for brain protection. This Research Topic focuses on the core issues related to perioperative brain health, including learning and memory, neuronal circuits for memory, postoperative cognitive dysfunction, postoperative delirium, and perioperative stroke, drawing from both experimental and clinical research.
We welcome Original Research, Review, Mini-Review, Case Report, and Opinion article types. Topics of interest include, but are not limited to:
? Postoperative cognitive dysfunction
? Postoperative delirium
? Perioperative sleep disorder
? Molecular and cellular mechanism of learning, memory, and anxiety
? Perioperative stroke
? Neural circuitry mechanism of cognitive function
Hundreds of millions of patients undergo anesthesia for surgery each year, making the adverse effects of anesthesia/surgery a significant public health concern. Among these adverse effects, perioperative neurocognitive disorder (PND) stands out as a critical issue. PNS refers to accelerated neurocognitive decline before and after anesthesia/surgery, including post-operative delirium, deficits in executive function, postoperative memory and cognitive dysfunction, postoperative personality change, sleep disorder, and perioperative stroke. However, the intrinsic mechanism between PND and anesthesia/surgery remains elusive, necessitating further research to identify the strategies to protect brain health during the perioperative period. There are a lot of questions that remain to be solved. For instance, the development of suitable animal models and detective methods for postoperative delirium research is yet to be accomplished. Additionally, there is a need to optimize pre-operative screen methods for susceptible populations of PND. Furthermore, more comprehensive investigations are required to understand the roles of neuroinflammation, neurodegeneration, glial cells, as well as the altered activity of neural circuits in PND.
In this Research Topic, we aim to gather the latest advances in perioperative neurocognitive disorders and explore the potential strategies for brain protection. This Research Topic focuses on the core issues related to perioperative brain health, including learning and memory, neuronal circuits for memory, postoperative cognitive dysfunction, postoperative delirium, and perioperative stroke, drawing from both experimental and clinical research.
We welcome Original Research, Review, Mini-Review, Case Report, and Opinion article types. Topics of interest include, but are not limited to:
? Postoperative cognitive dysfunction
? Postoperative delirium
? Perioperative sleep disorder
? Molecular and cellular mechanism of learning, memory, and anxiety
? Perioperative stroke
? Neural circuitry mechanism of cognitive function