Research Topic

Computerized Magnetic Resonance Imaging-Based Neuroimaging of Neurodegenerative Diseases

About this Research Topic

MRI is one of the core elements within the differential diagnostic work-up of patients with neurodegenerative diseases. Computerized magnetic resonance imaging (MRI)-based analyses are currently not routinely used for individual diagnosis in neurodegenerative diseases such as dementia syndromes, parkinsonian ...

MRI is one of the core elements within the differential diagnostic work-up of patients with neurodegenerative diseases. Computerized magnetic resonance imaging (MRI)-based analyses are currently not routinely used for individual diagnosis in neurodegenerative diseases such as dementia syndromes, parkinsonian syndromes, and motor neuron diseases. However, especially advanced MRI techniques have improved the anatomical understanding of pathomorphological alterations in various neurodegenerative diseases by quantitative comparisons between patients and controls at the group level.

The additional value of computer-based MRI with respect to diagnosis at the individual level and the potential use as a technical biological marker remains a subject of investigation by multiparametric MRI protocols, including voumetry/morphometry of T1-weighted 3-D MRI, diffusion-weighted imaging (DTI), and intrinsic functional connectivity MRI (ifc MRI).

Beyond the key-role of cross-sectional studies to identify regional affectation patterns of neurodegenerative diseases ('computer-based pathoanatomy'), it is a future task to expand these cross-sectional findings to group-based longitudinal markers. Currently, the concept of disease propagation in specific neurodegenerative diseases cannot be appropriately monitored by MRI-based neuroimaging tools, but promising approaches exist. Multi-platform, multi-protocol studies of different MRI metrics are increasingly used as instruments of research – studies within the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Neuroimaging society in Amyotrophic lateral sclerosis (NiSALS) have been integrating cross-platform data. Upon this basis, the potential of multiparametric neuroimaging will increase both as a biological marker and as an application to individual patient imaging (disease staging) in the framework of 'personalized medicine.'

The goal of this Research Topic is to give an overview on recent applications of multiparametric MRI to patients with various neurodegenerative diseases. Starting from applications at the group level, continuous progress of a transfer to individual diagnostic classification is reviewed and discussed.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

15 December 2017 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

15 December 2017 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top