The healthy intestine is not only beneficial to the digestion and absorption of nutrients but also a crucial safeguard against the invasion of pathogens. The intestinal mucosa is a particularly dynamic environment where the host constantly interacts with trillions of commensal microorganisms, and periodically interacts with pathogens of diverse natures. Destruction of intestinal homeostasis will lead to a damaged mucosal barrier, increased inflammatory responses, and dysbiosis of the gut microbiota, consequently triggering a variety of diseases. However, the gastrointestinal mucosa is constantly challenged by diet-derived and endogenously generated oxidants, mutagens, carcinogens, and pathogens. Therefore, research on how to maintain intestinal homeostasis is of great significance.
Within the gut, plant-based bioactive compounds have been demonstrated to benefit intestinal integrity and function, the immune system, and beneficial bacterial proliferation. Considering the complex chemical structure-activity relationship, these compounds could act on different cellular targets and consequently exert different activities in the intestine. Therefore, studies that focus on the role of plant-based bioactive compounds on intestinal homeostasis and further molecular mechanisms by targeting related signaling pathways, as well as the interactions between these pathways and gut microbiota in vitro and in vivo, are urgently needed. This can help us to comprehensively understand the meaning of the application of plant-based bioactive compounds in animal production or the healthcare industry.
The goal of this Research Topic is to explore the role the different plant-based bioactive compounds on intestinal homeostasis (including but not limited to the impacts on the intestinal barrier, absorption, immune function, and their interactions with the luminal microbiota) and their molecular mechanisms in vitro and in vivo, with an emphasis on how they could be translated into their use as dietary supplements in monogastric animal production to prevent gut disease or therapies to treat disease.
We welcome Original Research and Review articles from researchers in the fields of the following themes (but not limited to):
• Innovative plant-based bioactive compounds that can show beneficial effects on intestinal homeostasis, protective effects against gut disease, or therapies to treat disease;
• Analyze the composition of plant-based bioactive compounds that have beneficial effects on intestinal homeostasis, protective effects against gut disease, or therapies to treat disease;
• Explore the protective mechanisms from the aspects of the intestinal barrier, absorption, immune function, and their interactions with the luminal microbiota, etc.
The healthy intestine is not only beneficial to the digestion and absorption of nutrients but also a crucial safeguard against the invasion of pathogens. The intestinal mucosa is a particularly dynamic environment where the host constantly interacts with trillions of commensal microorganisms, and periodically interacts with pathogens of diverse natures. Destruction of intestinal homeostasis will lead to a damaged mucosal barrier, increased inflammatory responses, and dysbiosis of the gut microbiota, consequently triggering a variety of diseases. However, the gastrointestinal mucosa is constantly challenged by diet-derived and endogenously generated oxidants, mutagens, carcinogens, and pathogens. Therefore, research on how to maintain intestinal homeostasis is of great significance.
Within the gut, plant-based bioactive compounds have been demonstrated to benefit intestinal integrity and function, the immune system, and beneficial bacterial proliferation. Considering the complex chemical structure-activity relationship, these compounds could act on different cellular targets and consequently exert different activities in the intestine. Therefore, studies that focus on the role of plant-based bioactive compounds on intestinal homeostasis and further molecular mechanisms by targeting related signaling pathways, as well as the interactions between these pathways and gut microbiota in vitro and in vivo, are urgently needed. This can help us to comprehensively understand the meaning of the application of plant-based bioactive compounds in animal production or the healthcare industry.
The goal of this Research Topic is to explore the role the different plant-based bioactive compounds on intestinal homeostasis (including but not limited to the impacts on the intestinal barrier, absorption, immune function, and their interactions with the luminal microbiota) and their molecular mechanisms in vitro and in vivo, with an emphasis on how they could be translated into their use as dietary supplements in monogastric animal production to prevent gut disease or therapies to treat disease.
We welcome Original Research and Review articles from researchers in the fields of the following themes (but not limited to):
• Innovative plant-based bioactive compounds that can show beneficial effects on intestinal homeostasis, protective effects against gut disease, or therapies to treat disease;
• Analyze the composition of plant-based bioactive compounds that have beneficial effects on intestinal homeostasis, protective effects against gut disease, or therapies to treat disease;
• Explore the protective mechanisms from the aspects of the intestinal barrier, absorption, immune function, and their interactions with the luminal microbiota, etc.