Distinct helper T cell subsets are now known to be primed by different types of antigen presenting cells (APCs), and antigen presentation by atypical/non-professional cells is an area of intense ongoing research. This raises the question if antigen presentation is dependent on the specialization of professional APCs cells or whether any cell can rise to the challenge given an opportunity?
Emerging evidence suggests that it’s a combination of both, and in part relies on the transfer of antigens from non-professional cells such as mast cells to professional APCs like dendritic cells (DCs). Where do the lipid and metabolite antigens and non-MHC antigen presenting molecules fit in this scenario?
In this Research Topic, experts in the field are invited to submit articles which will review aspects of:
• Diversity and polarizing ability of non-professional cells as APCs - Mast cells
- Basophils
- Eosinophils
- Neutrophils
- Keratinocytes
- Endothelial cells
• Different APCs for lipid and metabolite antigen presentation
Distinct helper T cell subsets are now known to be primed by different types of antigen presenting cells (APCs), and antigen presentation by atypical/non-professional cells is an area of intense ongoing research. This raises the question if antigen presentation is dependent on the specialization of professional APCs cells or whether any cell can rise to the challenge given an opportunity?
Emerging evidence suggests that it’s a combination of both, and in part relies on the transfer of antigens from non-professional cells such as mast cells to professional APCs like dendritic cells (DCs). Where do the lipid and metabolite antigens and non-MHC antigen presenting molecules fit in this scenario?
In this Research Topic, experts in the field are invited to submit articles which will review aspects of:
• Diversity and polarizing ability of non-professional cells as APCs - Mast cells
- Basophils
- Eosinophils
- Neutrophils
- Keratinocytes
- Endothelial cells
• Different APCs for lipid and metabolite antigen presentation
