The role of telomeres in aging has been a hot topic since the Nobel Prize in Physiology or Medicine was awarded to telomere research in 2009. Increasing evidence from wet lab supports the observation that telomere dysregulation plays a major role in cellular aging. However, the extent to which this argument could be supported by population-based studies is largely unknown. Understanding how telomere dynamics affect aging is definitely of great importance to gain mechanistic insight. In particular, recent studies suggest that endocrine biomarkers, such as vitamin D and glycemic traits, are involved in the interplay between telomeres and aging. Additionally, epigenetic age is reported to be a more reliable and accurate biomarker of biological age compared with telomere length, and also regulates cellular senescence. Hence, it would be very interesting to examine the role of epigenetics in endocrinology and aging. Studies investigating the different roles of telomeres and epigenetics in endocrinology are particularly welcome.
With this Research Topic, we aim to provide an updated overview of both observational and experimental evidence in order to examine aging from the perspective of endocrinology, with a special focus on telomeres and epigenetics. Also, this Topic would like to focus on the interplay of these biomarkers. We believe that this Topic will contribute to our understanding of the aging process.
Investigators can contribute original research articles and review articles, as well as clinical studies that will stimulate the continuing efforts to understand aging and age-associated diseases.
The role of telomeres in aging has been a hot topic since the Nobel Prize in Physiology or Medicine was awarded to telomere research in 2009. Increasing evidence from wet lab supports the observation that telomere dysregulation plays a major role in cellular aging. However, the extent to which this argument could be supported by population-based studies is largely unknown. Understanding how telomere dynamics affect aging is definitely of great importance to gain mechanistic insight. In particular, recent studies suggest that endocrine biomarkers, such as vitamin D and glycemic traits, are involved in the interplay between telomeres and aging. Additionally, epigenetic age is reported to be a more reliable and accurate biomarker of biological age compared with telomere length, and also regulates cellular senescence. Hence, it would be very interesting to examine the role of epigenetics in endocrinology and aging. Studies investigating the different roles of telomeres and epigenetics in endocrinology are particularly welcome.
With this Research Topic, we aim to provide an updated overview of both observational and experimental evidence in order to examine aging from the perspective of endocrinology, with a special focus on telomeres and epigenetics. Also, this Topic would like to focus on the interplay of these biomarkers. We believe that this Topic will contribute to our understanding of the aging process.
Investigators can contribute original research articles and review articles, as well as clinical studies that will stimulate the continuing efforts to understand aging and age-associated diseases.
