About this Research Topic
Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors.
In this Research Topic, experts in this field will review aspects of:
1. Subsets of helper T cells in immunity and autoimmunity
2. Development and functions of pathogenic T cells in tissue inflammation
3. Interplay between effector and regulatory T cells in tissue inflammation
4. Molecular mechanisms of generation of pathogenic T cells
5. Targeting cytokines in autoimmunity
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