Research Topic

T Cell Differentiation and Function in Tissue Inflammation

About this Research Topic

Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the ...

Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors.

In this Research Topic, experts in this field will review aspects of:

1. Subsets of helper T cells in immunity and autoimmunity
2. Development and functions of pathogenic T cells in tissue inflammation
3. Interplay between effector and regulatory T cells in tissue inflammation
4. Molecular mechanisms of generation of pathogenic T cells
5. Targeting cytokines in autoimmunity


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Submission Deadlines

18 November 2017 Manuscript
31 January 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

18 November 2017 Manuscript
31 January 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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