T Cell Differentiation and Function in Tissue Inflammation

225K

views

86

authors

18

articles

T Cell Differentiation and Function in Tissue Inflammation

225K

views

86

authors

18

articles

Editorial

21 February 2020

Editorial: T Cell Differentiation and Function in Tissue Inflammation

Ritobrata Goswami

and

Amit Awasthi

12,171 views

13 citations

Editors

2

Translational Health Science and Technology Institute (THSTI)

Ritobrata Goswami

Indian Institute of Technology Kharagpur

Impact

About

Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors.

In this Research Topic, experts in this field will review aspects of:

1. Subsets of helper T cells in immunity and autoimmunity
2. Development and functions of pathogenic T cells in tissue inflammation
3. Interplay between effector and regulatory T cells in tissue inflammation
4. Molecular mechanisms of generation of pathogenic T cells
5. Targeting cytokines in autoimmunity

Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors.

In this Research Topic, experts in this field will review aspects of:

1. Subsets of helper T cells in immunity and autoimmunity
2. Development and functions of pathogenic T cells in tissue inflammation
3. Interplay between effector and regulatory T cells in tissue inflammation
4. Molecular mechanisms of generation of pathogenic T cells
5. Targeting cytokines in autoimmunity

Download ebook

Share

Editors

Translational Health Science and Technology Institute (THSTI)

Ritobrata Goswami

Indian Institute of Technology Kharagpur

Impact

224,985 Total views

168,699 Article views

51,916 Article downloads

4,370 Topic views

Published In

Journal Thumbnail

Frontiers in Immunology

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Suggest a topic