Chronic pain is an important personal and socio-economic burden, affecting more than 30% of people worldwide. It is highly disabling and associated with long-term affective and cognitive sequelae. Despite synergistic advances in basic and clinical research, some of the most severe conditions remain poorly managed, shifting from nociceptive nature to neuropathic and nociplastic components and major neuropsychiatric complications. Therefore, the understanding of pathophysiological mechanisms and the discovery of new pharmacological targets and innovative approaches are strongly awaited.
Important advances in basic research focus on the mechanistic aspect, offering no direct implication for novel therapeutic strategies. Conversely, the use of innovative therapies is not easily considered in clinical practice, breaking the process of translation for therapy. The primary goal of this Research Topic is to create a synergistic circularity of knowledge, merging clinical challenges with the latest pathophysiological findings in the field of pain and related neuropsychiatric disorders, with implications for pharmacological innovation. In addition, with a view to sustainability, particular attention will be given to compounds of natural origin, from new cannabinoids, alkaloids, and capsaicinoids to tannins, flavonoids, and other substances or approaches.
The Authors are invited to underlie the translational aspect of their research.
Themes:
-Physiology and pathophysiology of chronic pain and related disorders;
-Preclinical model characterization towards physiological systems implicated in pain;
-Novel therapeutic targets and compounds development;
-New technologies applied to pain pharmacological treatments;
-Innovative therapeutic approaches;
-Current clinical challenges related to analgesic therapy and pain-related complications.
-Optimization of therapy and personalized medicine.
Types of manuscript:
-Original Research Articles;
-Short communications;
-Systematic or Narrative Reviews;
-Opinion papers.
Chronic pain is an important personal and socio-economic burden, affecting more than 30% of people worldwide. It is highly disabling and associated with long-term affective and cognitive sequelae. Despite synergistic advances in basic and clinical research, some of the most severe conditions remain poorly managed, shifting from nociceptive nature to neuropathic and nociplastic components and major neuropsychiatric complications. Therefore, the understanding of pathophysiological mechanisms and the discovery of new pharmacological targets and innovative approaches are strongly awaited.
Important advances in basic research focus on the mechanistic aspect, offering no direct implication for novel therapeutic strategies. Conversely, the use of innovative therapies is not easily considered in clinical practice, breaking the process of translation for therapy. The primary goal of this Research Topic is to create a synergistic circularity of knowledge, merging clinical challenges with the latest pathophysiological findings in the field of pain and related neuropsychiatric disorders, with implications for pharmacological innovation. In addition, with a view to sustainability, particular attention will be given to compounds of natural origin, from new cannabinoids, alkaloids, and capsaicinoids to tannins, flavonoids, and other substances or approaches.
The Authors are invited to underlie the translational aspect of their research.
Themes:
-Physiology and pathophysiology of chronic pain and related disorders;
-Preclinical model characterization towards physiological systems implicated in pain;
-Novel therapeutic targets and compounds development;
-New technologies applied to pain pharmacological treatments;
-Innovative therapeutic approaches;
-Current clinical challenges related to analgesic therapy and pain-related complications.
-Optimization of therapy and personalized medicine.
Types of manuscript:
-Original Research Articles;
-Short communications;
-Systematic or Narrative Reviews;
-Opinion papers.
