The immune system, a paramount defender of the human body, exhibits a remarkable capacity for adaptive and diverse responses to a multitude of pathogens. This sophisticated response system is orchestrated through meticulous gene expression regulation within pivotal immune cells, including T cells, B cells, macrophages, and dendritic cells. At the heart of this regulation are two fundamental mechanisms: epigenetics, which alters gene accessibility, and transcription factors, which are instrumental in gene expression. This research endeavor delves into the sophisticated interplay between epigenetics and transcription in immune regulation. It aims to elucidate the core principles governing this complex interaction, tracing the journey from immune cell genesis to its specialized response against pathogens and neoplastic cells. Leveraging cutting-edge single-cell technologies and epigenomic profiling, this exploration seeks to unravel the nuances of this relationship, thereby paving the way for revolutionary therapeutic approaches in enhancing immune defenses, mitigating autoimmune responses, and optimizing inflammation for effective tissue repair and healing.
This Research Topic is dedicated to unraveling the pivotal roles of epigenetic mechanisms and transcription factors in immune system functionality. Our objective is to address and dissect the challenges posed by the dynamic and complex interplay between these two regulatory forces. We aim to shed light on the recent advancements and potential strategies for manipulating these pathways, encompassing the entire spectrum of immune regulation. Contributions are sought from diverse research domains, offering insights into the epigenetic landscapes, transcriptional regulators, external influences, inter-cellular communication, and prospective therapeutic interventions. This comprehensive inquiry will not only enhance our understanding of immune regulation but also provide a platform for presenting novel research findings, innovative methodologies, and critical insights. It is an invitation to contribute to an in-depth exploration of this intricate regulatory axis, driving forward the realms of immune health and personalized medical solutions.
We welcome researchers to contribute to our understanding of the multifaceted nature of immune regulation, with a special emphasis on the roles of epigenetics and transcription. This call for papers seeks to compile a diverse collection of studies, ranging from the molecular landscapes of DNA methylation and histone modifications to the cellular interplay dictating immune responses. We encourage submissions that explore the intricate patterns of epigenetic and transcriptional regulation, the impact of external stimuli on these patterns, and the resultant cellular communication and response. Moreover, we welcome papers proposing novel therapeutic strategies that leverage these regulatory pathways. This endeavor aims to map out the vast terrain of immune regulation, highlighting key regulatory elements and their roles in health and disease, thereby fostering advancements in immunotherapy and personalized medicine.
The immune system, a paramount defender of the human body, exhibits a remarkable capacity for adaptive and diverse responses to a multitude of pathogens. This sophisticated response system is orchestrated through meticulous gene expression regulation within pivotal immune cells, including T cells, B cells, macrophages, and dendritic cells. At the heart of this regulation are two fundamental mechanisms: epigenetics, which alters gene accessibility, and transcription factors, which are instrumental in gene expression. This research endeavor delves into the sophisticated interplay between epigenetics and transcription in immune regulation. It aims to elucidate the core principles governing this complex interaction, tracing the journey from immune cell genesis to its specialized response against pathogens and neoplastic cells. Leveraging cutting-edge single-cell technologies and epigenomic profiling, this exploration seeks to unravel the nuances of this relationship, thereby paving the way for revolutionary therapeutic approaches in enhancing immune defenses, mitigating autoimmune responses, and optimizing inflammation for effective tissue repair and healing.
This Research Topic is dedicated to unraveling the pivotal roles of epigenetic mechanisms and transcription factors in immune system functionality. Our objective is to address and dissect the challenges posed by the dynamic and complex interplay between these two regulatory forces. We aim to shed light on the recent advancements and potential strategies for manipulating these pathways, encompassing the entire spectrum of immune regulation. Contributions are sought from diverse research domains, offering insights into the epigenetic landscapes, transcriptional regulators, external influences, inter-cellular communication, and prospective therapeutic interventions. This comprehensive inquiry will not only enhance our understanding of immune regulation but also provide a platform for presenting novel research findings, innovative methodologies, and critical insights. It is an invitation to contribute to an in-depth exploration of this intricate regulatory axis, driving forward the realms of immune health and personalized medical solutions.
We welcome researchers to contribute to our understanding of the multifaceted nature of immune regulation, with a special emphasis on the roles of epigenetics and transcription. This call for papers seeks to compile a diverse collection of studies, ranging from the molecular landscapes of DNA methylation and histone modifications to the cellular interplay dictating immune responses. We encourage submissions that explore the intricate patterns of epigenetic and transcriptional regulation, the impact of external stimuli on these patterns, and the resultant cellular communication and response. Moreover, we welcome papers proposing novel therapeutic strategies that leverage these regulatory pathways. This endeavor aims to map out the vast terrain of immune regulation, highlighting key regulatory elements and their roles in health and disease, thereby fostering advancements in immunotherapy and personalized medicine.