Lymphocytes, including T/B cells as well as innate lymphoid cells (ILCs), are at the forefront of the body's defense system playing a pivotal role in maintaining health and fighting off pathogens and cancer cells. Their function is tightly regulated by cell-cell interactions and by a plethora of soluble factors that trigger a complex network of signaling cascades, ultimately leading to the generation of an appropriate cell response and to the elimination of the pathogens or cancer cells.
Disruption of the delicate regulatory network in lymphocytes can lead to diseases such as autoimmunity, immunodeficiency, and cancer. Understanding how these signaling pathways are regulated has been the focus of numerous brilliant researchers for decades. Despite significant advances, many molecular aspects of lymphocyte regulation remain unclear.
Research in this field aims to uncover valuable insights that can lead to new treatments for human diseases. In this Research Topic, we invite authors to contribute Original Research, Reviews, and Mini Reviews exploring the intricacies of lymphocyte signaling from health to disease.
Potential topics include, but are not limited to:
- Signaling pathways and transcription factors driving lymphoid differentiation and function, and their disruption in immunodeficiencies.
- Immune regulatory networks in autoimmunity and hypersensitivity, including novel therapeutic interventions.
- Signals regulating interactions between lymphoid cells and other cells in the tumor microenvironment.
- Key signaling molecules that can be targeted to enhance immune responses to pathogens and cancer.
Lymphocytes, including T/B cells as well as innate lymphoid cells (ILCs), are at the forefront of the body's defense system playing a pivotal role in maintaining health and fighting off pathogens and cancer cells. Their function is tightly regulated by cell-cell interactions and by a plethora of soluble factors that trigger a complex network of signaling cascades, ultimately leading to the generation of an appropriate cell response and to the elimination of the pathogens or cancer cells.
Disruption of the delicate regulatory network in lymphocytes can lead to diseases such as autoimmunity, immunodeficiency, and cancer. Understanding how these signaling pathways are regulated has been the focus of numerous brilliant researchers for decades. Despite significant advances, many molecular aspects of lymphocyte regulation remain unclear.
Research in this field aims to uncover valuable insights that can lead to new treatments for human diseases. In this Research Topic, we invite authors to contribute Original Research, Reviews, and Mini Reviews exploring the intricacies of lymphocyte signaling from health to disease.
Potential topics include, but are not limited to:
- Signaling pathways and transcription factors driving lymphoid differentiation and function, and their disruption in immunodeficiencies.
- Immune regulatory networks in autoimmunity and hypersensitivity, including novel therapeutic interventions.
- Signals regulating interactions between lymphoid cells and other cells in the tumor microenvironment.
- Key signaling molecules that can be targeted to enhance immune responses to pathogens and cancer.