Despite considerable progress in gastroenterology in recent decades, the incidence of diseases of the digestive system remains unsatisfactorily high. The stability of the gastrointestinal tract is crucially supported by its multiple barriers, such as the protective microbiome, the regulating mucus layers, the structurally integral epithelial barrier, and the responsive subepithelial immune system. Each of these components not only defends against but can also be vulnerable to pathogenic threats, presenting ongoing challenges and opportunities for novel barrier-improving therapies.
This Research Topic aims to explore new and existing treatments that enhance mucosal homeostasis, microbiota, epithelial barrier function, and the immune system. Special emphasis is on the prevention and treatment of gastroenteritis, common pathogens like Campylobacter or Helicobacter, and the development of strategies against biofilm formation and improving antimicrobial and antibiofilm effectiveness.
To advance understanding and treatments in the maintenance and protection of the gastrointestinal tract, we encourage contributions on the following topics:
•Studies on the permeation of bacterial toxins, polysaccharides, and other microbial antigens.
•Research on bioactive substances' permeability and absorbance.
•Investigations into epithelial barrier-enhancing compounds.
•Examinations of microorganism adherence, mucus and biofilm formation, and antibiofilm compounds.
•Analyses of microbiome modification, microbial community dynamics, and antimicrobial actions.
•Analysis of immune response modulation, solutions for leaky gut, and anti-inflammatory treatments.
•Reviews on pharmaceutical agents, drug repurposing initiatives, and ethnopharmacological practices.
We seek submissions of original research, insightful reviews, and brief reports that bring new perspectives to this critical area of health
Despite considerable progress in gastroenterology in recent decades, the incidence of diseases of the digestive system remains unsatisfactorily high. The stability of the gastrointestinal tract is crucially supported by its multiple barriers, such as the protective microbiome, the regulating mucus layers, the structurally integral epithelial barrier, and the responsive subepithelial immune system. Each of these components not only defends against but can also be vulnerable to pathogenic threats, presenting ongoing challenges and opportunities for novel barrier-improving therapies.
This Research Topic aims to explore new and existing treatments that enhance mucosal homeostasis, microbiota, epithelial barrier function, and the immune system. Special emphasis is on the prevention and treatment of gastroenteritis, common pathogens like Campylobacter or Helicobacter, and the development of strategies against biofilm formation and improving antimicrobial and antibiofilm effectiveness.
To advance understanding and treatments in the maintenance and protection of the gastrointestinal tract, we encourage contributions on the following topics:
•Studies on the permeation of bacterial toxins, polysaccharides, and other microbial antigens.
•Research on bioactive substances' permeability and absorbance.
•Investigations into epithelial barrier-enhancing compounds.
•Examinations of microorganism adherence, mucus and biofilm formation, and antibiofilm compounds.
•Analyses of microbiome modification, microbial community dynamics, and antimicrobial actions.
•Analysis of immune response modulation, solutions for leaky gut, and anti-inflammatory treatments.
•Reviews on pharmaceutical agents, drug repurposing initiatives, and ethnopharmacological practices.
We seek submissions of original research, insightful reviews, and brief reports that bring new perspectives to this critical area of health