Emerging Horizons of Metformin: Exploring Recent Advances and Addressing Challenges in Research and Clinical Utilization

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SYSTEMATIC REVIEW

Published on 26 Jun 2025

Systematic review and meta-analysis of current guidelines, and their evidence base, on risk of renal function after administration of contrast medium for diabetic patients receiving metformin

Qinhui Xu
Weixing Huang
Qianyun Li
Tongan Bao
Hua Luo
Xiao Luo

doi 10.3389/fmed.2025.1547725

820 views

CLINICAL TRIAL

Published on 02 May 2025

Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson’s disease

Hayam Ali AlRasheed
Mostafa M. Bahaa
Thanaa A. Elmasry
Eman I. Elberri
Fedaa A. Kotkata
Ramy M. El Sabaa
Yasmine M. Elmorsi
Mostafa M. Kamel
Walaa A. Negm
8 more
Mahmoud S. Abdallah

doi 10.3389/fphar.2025.1497261

2,223 views

REVIEW

Published on 22 Apr 2025

Metformin in gynecological disorders: pathogenic insights and therapeutic implications

Ping Nie
Minghua Wang
Yan Mo
Hong Zhou
Qingbing Zha
Gendie E. Lash
Ping Li

doi 10.3389/fphar.2025.1526709

2,722 views

ORIGINAL RESEARCH

Published on 26 Mar 2025

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway

Yanwei Liu
Zhaoyu Fu
Xinyu Wang
Qifan Yang
Shun Liu
Dong Zhu

doi 10.3389/fphar.2025.1527316

1,938 views

ORIGINAL RESEARCH

Published on 20 Mar 2025

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration

Xin Wang
Xu Liang
Shiya Huang
Mingyan Wei
Yuan Xu
Xiaodong Chen
Yanliang Miao
Rongrong Zong
Xiang Lin
2 more
Qian Chen

doi 10.3389/fphar.2025.1547492

1,431 views
1 citation

CLINICAL TRIAL

Published on 19 Mar 2025

The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study

Ammena Y. Binsaleh
Sahar M. El-Haggar
Sahar K. Hegazy
Maha M. Maher
Monir M. Bahgat
Thanaa A. Elmasry
Sarah Alrubia
Amsha S. Alsegiani
Mamdouh Eldesoqui
Mostafa M. Bahaa

doi 10.3389/fphar.2025.1507009

1,764 views
1 citation

ORIGINAL RESEARCH

Published on 19 Mar 2025

Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health

Iryna Halabitska
Pavlo Petakh
Oleksandr Kamyshnyi

doi 10.3389/fphar.2025.1567544

1,404 views
1 citation

BRIEF RESEARCH REPORT

Published on 31 Jan 2025

Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF

Valentina N. Nikolić
Milan Stefanović
Dejan Mitić
Slavica Sunarić
Vladana Stojiljkovic
Hristina Trajković
Aleksandra Ignjatović
Dragana Stokanović

doi 10.3389/fphar.2024.1505022

1,212 views

PERSPECTIVE

Published on 10 Dec 2024

Revolutionary drug repositioning: the preventive and therapeutic potential of metformin and other antidiabetic drugs in age-related macular degeneration

Yating Zhou
Fei Xue

doi 10.3389/fphar.2024.1507860

1,451 views
2 citations

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Translational Pharmacology

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Articles

Systematic review and meta-analysis of current guidelines, and their evidence base, on risk of renal function after administration of contrast medium for diabetic patients receiving metformin

Randomized, double-blind, placebo-controlled pilot study of metformin as an adjunctive therapy in Parkinson’s disease

Metformin in gynecological disorders: pathogenic insights and therapeutic implications

Metformin attenuates diabetic osteoporosis by suppressing ferroptosis via the AMPK/Nrf2 pathway

Metformin inhibits pathological retinal neovascularization but promotes retinal fibrosis in experimental neovascular age-related macular degeneration

The adjunctive role of metformin in patients with mild to moderate ulcerative colitis: a randomized controlled study

Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health

Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF

Revolutionary drug repositioning: the preventive and therapeutic potential of metformin and other antidiabetic drugs in age-related macular degeneration

Frontiers in Pharmacology

Translational Pharmacology