The exploration of metformin, a widely used oral biguanide for managing type 2 diabetes, has unveiled its potential in a spectrum of non-diabetic conditions, including cancer, cardiovascular diseases, and polycystic ovary syndrome. Despite its extensive use, the detailed mechanisms by which metformin operates, its efficacy across different conditions, and its side effect profile are not fully understood. This presents a unique opportunity to delve deeper into metformin's multifaceted roles, addressing both its therapeutic potential and its limitations.
In this Research Topic, we aim to consolidate and advance the body of knowledge surrounding metformin by welcoming articles that:
1. Investigate the molecular mechanisms of action and pharmacokinetics of metformin, identifying how it interacts with cellular signaling pathways and metabolic processes.
2. Analyze metformin’s efficacy and therapeutic potential in various non-diabetic conditions, including but not limited to cancer, cardiovascular diseases, and polycystic ovary syndrome. Comparative studies illustrating its benefits and risks across different patient populations are highly encouraged.
3. Explore the synergistic effects of metformin when used in combination with other medications, elucidating novel therapeutic strategies and enhancing treatment efficacy.
4. Offer a critical review of the side effects and limitations associated with metformin use, aiming to provide insights into improved management and mitigation strategies.
To ensure a focused and comprehensive collection, we particularly encourage submissions that:
Probe into the cellular and molecular pathways influenced by metformin in specific non-diabetic diseases, delineating its exact role and potential mechanisms of synergy or antagonism with other treatments.
Present novel therapeutic strategies involving metformin that could pave the way for clinical trials, including dose optimization and personalized medicine approaches.
Detail metformin's impact on metabolic health beyond glucose regulation, such as its effects on lipid metabolism, inflammation, and mitochondrial function.
Address gaps in understanding regarding patient-specific responses to metformin, influenced by genetic, epigenetic, or environmental factors.
Investigate the interaction of metformin with dietary intakes and diet patterns.
Through this focused collection, we aspire to build a comprehensive and nuanced understanding of metformin’s multifaceted roles in health and disease. By fostering interdisciplinary research and clinical investigation, this collection aims to enhance patient care, broaden clinical applications, and contribute substantially to the field of metabolism and chronic disease management. We invite researchers to contribute their novel findings and perspectives, strengthening the scientific foundation underpinning metformin's clinical and therapeutic landscape.
The exploration of metformin, a widely used oral biguanide for managing type 2 diabetes, has unveiled its potential in a spectrum of non-diabetic conditions, including cancer, cardiovascular diseases, and polycystic ovary syndrome. Despite its extensive use, the detailed mechanisms by which metformin operates, its efficacy across different conditions, and its side effect profile are not fully understood. This presents a unique opportunity to delve deeper into metformin's multifaceted roles, addressing both its therapeutic potential and its limitations.
In this Research Topic, we aim to consolidate and advance the body of knowledge surrounding metformin by welcoming articles that:
1. Investigate the molecular mechanisms of action and pharmacokinetics of metformin, identifying how it interacts with cellular signaling pathways and metabolic processes.
2. Analyze metformin’s efficacy and therapeutic potential in various non-diabetic conditions, including but not limited to cancer, cardiovascular diseases, and polycystic ovary syndrome. Comparative studies illustrating its benefits and risks across different patient populations are highly encouraged.
3. Explore the synergistic effects of metformin when used in combination with other medications, elucidating novel therapeutic strategies and enhancing treatment efficacy.
4. Offer a critical review of the side effects and limitations associated with metformin use, aiming to provide insights into improved management and mitigation strategies.
To ensure a focused and comprehensive collection, we particularly encourage submissions that:
Probe into the cellular and molecular pathways influenced by metformin in specific non-diabetic diseases, delineating its exact role and potential mechanisms of synergy or antagonism with other treatments.
Present novel therapeutic strategies involving metformin that could pave the way for clinical trials, including dose optimization and personalized medicine approaches.
Detail metformin's impact on metabolic health beyond glucose regulation, such as its effects on lipid metabolism, inflammation, and mitochondrial function.
Address gaps in understanding regarding patient-specific responses to metformin, influenced by genetic, epigenetic, or environmental factors.
Investigate the interaction of metformin with dietary intakes and diet patterns.
Through this focused collection, we aspire to build a comprehensive and nuanced understanding of metformin’s multifaceted roles in health and disease. By fostering interdisciplinary research and clinical investigation, this collection aims to enhance patient care, broaden clinical applications, and contribute substantially to the field of metabolism and chronic disease management. We invite researchers to contribute their novel findings and perspectives, strengthening the scientific foundation underpinning metformin's clinical and therapeutic landscape.