About this Research Topic
Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.
In this Research Topic, we seek to establish a platform that promotes active and efficient publication of Shankopathy-related results and exchanges of opinions. We would like to solicit manuscripts on Shankopathies with focuses at various levels, including genes, proteins, cells, synapses, neural circuits, behaviors, and environments.
Keywords: Psychiatric disorders, autism spetrum disorders, intellectual disability, schizophrenia, Shank
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