Research Topic

Synovial Pathobiology and Pathogenesis of Inflammatory Arthritis

About this Research Topic

Synovial tissue has long been recognized as the target organ in inflammatory arthritis and as such has been extensively studied and evaluated to better understand disease pathogenesis. It is widely acknowledged that the synovial tissue has a heterogenous spectrum of inflammatory/immune cell infiltrate and this is paralleled by a similarly diverse expression of molecular markers. Although outcome for patients with early inflammatory arthritis has improved significantly considerable challenges remain including targeting intensive therapeutic regimens to those both most likely to respond and with the worse prognosis. Thus pathobiological heterogeneity has led to a search for tissue biomarkers of diagnosis, prognosis and response to therapy.

The proposed research topic therefore aims to address a number of the key current outstanding research questions regarding the role of synovial tissue in pathogenesis of inflammatory arthritis including the role of synovial pathobiology in diagnosis, prognosis and response to therapeutic intervention.


Keywords: synovial, histology, pathogenesis, inflammatory arthritis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Synovial tissue has long been recognized as the target organ in inflammatory arthritis and as such has been extensively studied and evaluated to better understand disease pathogenesis. It is widely acknowledged that the synovial tissue has a heterogenous spectrum of inflammatory/immune cell infiltrate and this is paralleled by a similarly diverse expression of molecular markers. Although outcome for patients with early inflammatory arthritis has improved significantly considerable challenges remain including targeting intensive therapeutic regimens to those both most likely to respond and with the worse prognosis. Thus pathobiological heterogeneity has led to a search for tissue biomarkers of diagnosis, prognosis and response to therapy.

The proposed research topic therefore aims to address a number of the key current outstanding research questions regarding the role of synovial tissue in pathogenesis of inflammatory arthritis including the role of synovial pathobiology in diagnosis, prognosis and response to therapeutic intervention.


Keywords: synovial, histology, pathogenesis, inflammatory arthritis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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