Intercellular communication in chronic neuroinflammatory diseases

Neuroinflammation represents a hallmark of many degenerative diseases, such as Alzheimer’s Disease, Parkinson’s Disease, amyotrophic lateral sclerosis, multiple sclerosis, multiple system atrophy and neuropathic pain. Inflammatory states affecting the central nervous system (CNS) are characterized by the activation of immune responses within the CNS, which involves a complex interplay between either resident and infiltrating immune cells and a range of signaling molecules including cytokines and chemokines.



The characterization of critical factors driving the chronicization process of inflammatory-based pathophysiological processes represents one of the most significant challenges in identifying suitable therapeutic interventions. Understanding the roles and interactions of CNS cells and the molecular mediators involved in neuroinflammation is crucial for developing targeted therapies to modulate this process and mitigate its harmful effects on neuronal health in neurodegenerative diseases.



This Research Topic, seeks Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report, and Opinion articles that cover, but are not limited to, the following topics:

1. Neuroglia in chronic neuroinflammation

2. Intercellular communication

3. Modulation of the immune responses

4. Cellular mediators in sustaining chronicization

5. Neural homeostasis and suffering

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Astrocyte, microglia, cell signaling, inflammation, neurodegeneration

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.