Neuroinflammation represents a hallmark of many degenerative diseases, such as Alzheimer’s Disease, Parkinson’s Disease, amyotrophic lateral sclerosis, multiple sclerosis, multiple system atrophy and neuropathic pain. Inflammatory states affecting the central nervous system (CNS) are characterized by the activation of immune responses within the CNS, which involves a complex interplay between either resident and infiltrating immune cells and a range of signaling molecules including cytokines and chemokines.The characterization of critical factors driving the chronicization process of inflammatory-based pathophysiological processes represents one of the most significant challenges in identifying suitable therapeutic interventions. Understanding the roles and interactions of CNS cells and the molecular mediators involved in neuroinflammation is crucial for developing targeted therapies to modulate this process and mitigate its harmful effects on neuronal health in neurodegenerative diseases.This Research Topic, seeks Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report, and Opinion articles that cover, but are not limited to, the following topics:1. Neuroglia in chronic neuroinflammation2. Intercellular communication3. Modulation of the immune responses4. Cellular mediators in sustaining chronicization 5. Neural homeostasis and suffering
Neuroinflammation represents a hallmark of many degenerative diseases, such as Alzheimer’s Disease, Parkinson’s Disease, amyotrophic lateral sclerosis, multiple sclerosis, multiple system atrophy and neuropathic pain. Inflammatory states affecting the central nervous system (CNS) are characterized by the activation of immune responses within the CNS, which involves a complex interplay between either resident and infiltrating immune cells and a range of signaling molecules including cytokines and chemokines.The characterization of critical factors driving the chronicization process of inflammatory-based pathophysiological processes represents one of the most significant challenges in identifying suitable therapeutic interventions. Understanding the roles and interactions of CNS cells and the molecular mediators involved in neuroinflammation is crucial for developing targeted therapies to modulate this process and mitigate its harmful effects on neuronal health in neurodegenerative diseases.This Research Topic, seeks Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report, and Opinion articles that cover, but are not limited to, the following topics:1. Neuroglia in chronic neuroinflammation2. Intercellular communication3. Modulation of the immune responses4. Cellular mediators in sustaining chronicization 5. Neural homeostasis and suffering