Tissue-resident macrophages are crucial players in the immune system, acting as the first line of defense and maintaining tissue homeostasis by responding to various environmental challenges and infections. These macrophages are highly diverse, and their functionality varies based on their tissue-specific location. A key focus in contemporary immunological research is understanding how these cells contribute to both protective immune responses and inappropriate autoimmune processes. Autoinflammatory and autoimmune diseases often involve malfunctioning macrophages that produce pro-inflammatory cytokines, leading to chronic inflammation and immune responses against self-antigens. The current understanding of tissue-resident macrophages highlights their importance in regulating immune responses and promoting tissue repair, yet much remains to be discovered to fully grasp their roles in both normal and pathological states.
This Research Topic aims to uncover the intricate dynamics of tissue-resident macrophages within the immune system, particularly their functional heterogeneity and interactions with other immune cells. The research will address significant questions about the origins and differentiation of these cells in various tissue environments, their involvement in maintaining immune homeostasis, and their contributions to infection and autoimmune disease pathogenesis. By investigating these aspects, the research seeks to bridge the existing gaps in knowledge and potentially pave the way for novel therapeutic interventions targeting macrophages in autoimmune and infectious diseases.
To gather further insights into the multifaceted roles of tissue-resident macrophages, we welcome articles addressing, but not limited to, the following themes:
- The precise origins and lineage of tissue-resident macrophages across different tissues.
- Tissue-specific signals influencing macrophage differentiation and maintenance.
- Mechanisms underlying functional heterogeneity among macrophages in different tissues.
- Interactions between tissue-resident macrophages and other immune cells in autoimmune pathogenesis.
- The role of macrophages in balancing immune activation and maintaining tolerance.
- Contributions of macrophages to the pathology of chronic inflammatory diseases.
We welcome submissions of original research, reviews, mini-reviews, perspectives, and brief research reports.
Tissue-resident macrophages are crucial players in the immune system, acting as the first line of defense and maintaining tissue homeostasis by responding to various environmental challenges and infections. These macrophages are highly diverse, and their functionality varies based on their tissue-specific location. A key focus in contemporary immunological research is understanding how these cells contribute to both protective immune responses and inappropriate autoimmune processes. Autoinflammatory and autoimmune diseases often involve malfunctioning macrophages that produce pro-inflammatory cytokines, leading to chronic inflammation and immune responses against self-antigens. The current understanding of tissue-resident macrophages highlights their importance in regulating immune responses and promoting tissue repair, yet much remains to be discovered to fully grasp their roles in both normal and pathological states.
This Research Topic aims to uncover the intricate dynamics of tissue-resident macrophages within the immune system, particularly their functional heterogeneity and interactions with other immune cells. The research will address significant questions about the origins and differentiation of these cells in various tissue environments, their involvement in maintaining immune homeostasis, and their contributions to infection and autoimmune disease pathogenesis. By investigating these aspects, the research seeks to bridge the existing gaps in knowledge and potentially pave the way for novel therapeutic interventions targeting macrophages in autoimmune and infectious diseases.
To gather further insights into the multifaceted roles of tissue-resident macrophages, we welcome articles addressing, but not limited to, the following themes:
- The precise origins and lineage of tissue-resident macrophages across different tissues.
- Tissue-specific signals influencing macrophage differentiation and maintenance.
- Mechanisms underlying functional heterogeneity among macrophages in different tissues.
- Interactions between tissue-resident macrophages and other immune cells in autoimmune pathogenesis.
- The role of macrophages in balancing immune activation and maintaining tolerance.
- Contributions of macrophages to the pathology of chronic inflammatory diseases.
We welcome submissions of original research, reviews, mini-reviews, perspectives, and brief research reports.