Extracellular vesicles (EVs) are a growing area of research within the field of immunology, particularly concerning their role in inflammation. These small lipid vesicles, which carry nucleic acids and proteins, are released by nearly all cell types, including bacteria, and have been increasingly recognized as pivotal regulators of immune responses in both acute and chronic inflammatory conditions. Recent studies have identified EVs as key drivers of matrix remodeling and cellular communication across various cell types and diseases. While the role of EVs in cancer has been extensively explored, there is a growing interest in understanding how EVs influence immune cell behavior and the reciprocal effects of immune cells on tissue-resident cells through EVs. Despite significant advancements, there remain gaps in our understanding of the precise mechanisms by which EVs modulate inflammation, necessitating further investigation into their complex roles and interactions.This Research Topic aims to highlight cutting-edge research on the role of EVs in the modulation of acute and chronic inflammation. The primary objective is to elucidate how EVs affect immune cell function and how immune cell-derived EVs influence tissue responses. By addressing these questions, the research seeks to uncover novel insights into the mechanisms of EV-mediated communication in inflammatory processes, potentially leading to new therapeutic strategies for managing inflammation-related diseases.To gather further insights into the role of EVs in inflammation, we welcome articles addressing, but not limited to, the following themes:- Mechanisms of EV release and uptake in immune cells.- The impact of EVs on immune cell signaling pathways.- The role of EVs in intercellular communication during inflammation.- EV-mediated modulation of tissue-resident cells in inflammatory environments.- Therapeutic potential of targeting EVs in inflammatory diseases.- Comparative studies of EVs in acute versus chronic inflammation.
Extracellular vesicles (EVs) are a growing area of research within the field of immunology, particularly concerning their role in inflammation. These small lipid vesicles, which carry nucleic acids and proteins, are released by nearly all cell types, including bacteria, and have been increasingly recognized as pivotal regulators of immune responses in both acute and chronic inflammatory conditions. Recent studies have identified EVs as key drivers of matrix remodeling and cellular communication across various cell types and diseases. While the role of EVs in cancer has been extensively explored, there is a growing interest in understanding how EVs influence immune cell behavior and the reciprocal effects of immune cells on tissue-resident cells through EVs. Despite significant advancements, there remain gaps in our understanding of the precise mechanisms by which EVs modulate inflammation, necessitating further investigation into their complex roles and interactions.This Research Topic aims to highlight cutting-edge research on the role of EVs in the modulation of acute and chronic inflammation. The primary objective is to elucidate how EVs affect immune cell function and how immune cell-derived EVs influence tissue responses. By addressing these questions, the research seeks to uncover novel insights into the mechanisms of EV-mediated communication in inflammatory processes, potentially leading to new therapeutic strategies for managing inflammation-related diseases.To gather further insights into the role of EVs in inflammation, we welcome articles addressing, but not limited to, the following themes:- Mechanisms of EV release and uptake in immune cells.- The impact of EVs on immune cell signaling pathways.- The role of EVs in intercellular communication during inflammation.- EV-mediated modulation of tissue-resident cells in inflammatory environments.- Therapeutic potential of targeting EVs in inflammatory diseases.- Comparative studies of EVs in acute versus chronic inflammation.