Two of the main recurring phenotypic and transcriptomic signatures in long-lived mouse models are: 1) Reduced inflammatory signals and 2) An altered metabolism that shifts towards increased reliance on fatty acid oxidation. Conversely, aging is typically correlated with a phenotype of reduced fatty acid oxidation capacity and elevated inflammation across multiple tissue types. The interconnectivity between these two biological phenomena has been well established in certain cell types, where increased fatty acid oxidation leads to lower inflammation and vice versa.
This research topic aims to explore and advance our understanding of the complex interplay between metabolic processes and inflammatory responses, specifically, how these biological phenomena pertain to aging and lifespan extension and how these processes mutually influence one another. We seek to determine if there is a causal link between inflammation and metabolic changes in aging, longevity, or age-related disease models. Additionally, we will explore whether particular inflammatory signaling cascades, such as Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) and Signal Transducer and Activator of Transcription (STAT) pathways, are subject to modulation in the context of metabolic perturbations. Our collection also plans to investigate if specific metabolic pathways, including but not limited to fatty acid oxidation and the tricarboxylic acid (TCA) cycle, are susceptible to modification in response to pro-inflammatory or immunological stimuli. Ultimately, this study aims to uncover whether the direct alteration of metabolic or inflammatory mechanisms can lead to health or lifespan benefits.
To do this, we seek original research articles, review articles and others that investigate the link between inflammation and metabolic changes in aging, longevity, or age-related disease. Themes of interest include, but are not limited to
• Clinical and experimental studies that explore the association between metabolism and inflammatory/immune responses with aging.
• Clinical and experimental studies that explore the association between metabolism and inflammatory/immune responses with lifespan extension.
• Mechanistic or omics-oriented studies that dissect the crosstalk between different metabolic pathways and pro- or anti-inflammatory mechanisms in the contexts of aging, age-related pathologies, or extended longevity.
Two of the main recurring phenotypic and transcriptomic signatures in long-lived mouse models are: 1) Reduced inflammatory signals and 2) An altered metabolism that shifts towards increased reliance on fatty acid oxidation. Conversely, aging is typically correlated with a phenotype of reduced fatty acid oxidation capacity and elevated inflammation across multiple tissue types. The interconnectivity between these two biological phenomena has been well established in certain cell types, where increased fatty acid oxidation leads to lower inflammation and vice versa.
This research topic aims to explore and advance our understanding of the complex interplay between metabolic processes and inflammatory responses, specifically, how these biological phenomena pertain to aging and lifespan extension and how these processes mutually influence one another. We seek to determine if there is a causal link between inflammation and metabolic changes in aging, longevity, or age-related disease models. Additionally, we will explore whether particular inflammatory signaling cascades, such as Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-?B) and Signal Transducer and Activator of Transcription (STAT) pathways, are subject to modulation in the context of metabolic perturbations. Our collection also plans to investigate if specific metabolic pathways, including but not limited to fatty acid oxidation and the tricarboxylic acid (TCA) cycle, are susceptible to modification in response to pro-inflammatory or immunological stimuli. Ultimately, this study aims to uncover whether the direct alteration of metabolic or inflammatory mechanisms can lead to health or lifespan benefits.
To do this, we seek original research articles, review articles and others that investigate the link between inflammation and metabolic changes in aging, longevity, or age-related disease. Themes of interest include, but are not limited to
• Clinical and experimental studies that explore the association between metabolism and inflammatory/immune responses with aging.
• Clinical and experimental studies that explore the association between metabolism and inflammatory/immune responses with lifespan extension.
• Mechanistic or omics-oriented studies that dissect the crosstalk between different metabolic pathways and pro- or anti-inflammatory mechanisms in the contexts of aging, age-related pathologies, or extended longevity.