Research Topic

Changes in Molecular Expression after Memory Acquisition and Plasticity. Looking for the Memory Trace

About this Research Topic

Memory trace can be defined as the physical mark of an acquired memory. Several hypotheses have
been established trying to determine how the engram is codified and where it is located in different
brain structures. It is well known that, after memory acquisition or plasticity induction, protein
translation and gene expression is required, as well as protein acetylation, ubiquitination and
proteasome activity. These processes take place along several time waves, starting immediately after
memory acquisition and continuing during memory consolidation. For this reason, many molecular
changes are proposed as markers of the memory trace. Moreover, it has been shown that changes in
gene expression, knocking down or overexpression of several proteins in specific brain structures can
lead to deficits in memory retrieval. Furthermore, there is evidence that some circuit changes are
associated to the memory encoding. However, until today, there has been little evidence to clarify these
concepts.

The goal of this Research topic is to discuss known data and to discover the latest advances in this area.
We aim to join the latest advances in original research as well as actualized reviews that contribute to
analyze and discuss new ideas and recent discoveries in this area.


Keywords: LTM, Synaptic Plasticity, gene expression, neural circuits


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Memory trace can be defined as the physical mark of an acquired memory. Several hypotheses have
been established trying to determine how the engram is codified and where it is located in different
brain structures. It is well known that, after memory acquisition or plasticity induction, protein
translation and gene expression is required, as well as protein acetylation, ubiquitination and
proteasome activity. These processes take place along several time waves, starting immediately after
memory acquisition and continuing during memory consolidation. For this reason, many molecular
changes are proposed as markers of the memory trace. Moreover, it has been shown that changes in
gene expression, knocking down or overexpression of several proteins in specific brain structures can
lead to deficits in memory retrieval. Furthermore, there is evidence that some circuit changes are
associated to the memory encoding. However, until today, there has been little evidence to clarify these
concepts.

The goal of this Research topic is to discuss known data and to discover the latest advances in this area.
We aim to join the latest advances in original research as well as actualized reviews that contribute to
analyze and discuss new ideas and recent discoveries in this area.


Keywords: LTM, Synaptic Plasticity, gene expression, neural circuits


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

29 December 2017 Abstract
29 June 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

29 December 2017 Abstract
29 June 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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