About this Research Topic
Memory trace can be defined as the physical mark of an acquired memory. Several hypotheses have
been established trying to determine how the engram is codified and where it is located in different
brain structures. It is well known that, after memory acquisition or plasticity induction, protein
translation and gene expression is required, as well as protein acetylation, ubiquitination and
proteasome activity. These processes take place along several time waves, starting immediately after
memory acquisition and continuing during memory consolidation. For this reason, many molecular
changes are proposed as markers of the memory trace. Moreover, it has been shown that changes in
gene expression, knocking down or overexpression of several proteins in specific brain structures can
lead to deficits in memory retrieval. Furthermore, there is evidence that some circuit changes are
associated to the memory encoding. However, until today, there has been little evidence to clarify these
The goal of this Research topic is to discuss known data and to discover the latest advances in this area.
We aim to join the latest advances in original research as well as actualized reviews that contribute to
analyze and discuss new ideas and recent discoveries in this area.
Keywords: LTM, Synaptic Plasticity, gene expression, neural circuits
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