About this Research Topic
There is an urgent need for new therapeutic targets and biomarkers that can predict the incidence and the prognosis of these diseases. In particular, there remains a significant gap in our understanding of the cellular and molecular biology of these diseases to develop new therapeutic targets and diagnostic tools. Therefore, there is a great need to develop new therapeutic approaches that can be used in patients with cerebrovascular diseases and neurodegenerative diseases.
Over the past few decades, most efforts have focused on the cellular, neurochemical and molecular events responsible for the susceptibility of neurons to injury, and on the development of strategies aimed at protecting neurons from the consequences of ischemia and degeneration. However, relatively less attention has been paid to the pathology of cerebral blood vessels, astrocytes, microglia and pericytes.
This Research Topic aims at a multifaceted approach to evaluating recent progress in our understanding of the cellular and molecular biology of these diseases.
Research articles and review papers are welcome from scientists working in the areas of i) brain cellular and vascular biochemistry and molecular biology and their relationships to brain development; ii) morphological analysis of brain structure after cerebrovascular and neurodegenerative diseases; iv) the molecular and cellular events underlying the development of cerebral blood vessels and their relationships to brain development; v) the factors controlling the functional interaction between endothelial cells, neurons and glia; vi) studies of membrane channels and proteins; vii) perivascular status of the brain and functions of the blood brain barrier in health and disease; viii) protective mechanism of brain and new therapeutic targets.
Keywords: Cerebrovascular disease, Ischaemic Stroke, haemorrhagic stroke, Neurodegeneration, Alzheimer’s disease
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