About this Research Topic
This pattern of expression is particularly suitable as a substrate for designing novel agents against pain and emotional disorders, these latter showing wide co-morbidity with chronic pain. Among mGluRs, those of Group III (mGluR4, mGluR6, mGluR7, and mGluR8) are less defined due to the lack of selective ligands. Excepting mGluR6, Group III mGluRs are widely distributed throughout the CNS at presynaptic terminals, where they inhibit neurotransmitter release at glutamatergic and γ-aminobutyric acid (GABA)ergic synapses. Novel selective and brain penetrable ligands for Group III mGluR subtypes have been recently developed that mainly target allosteric sites, acting as positive or negative allosteric modulators (PAMs or NAMs) of glutamate transmission. These compounds contribute to the understanding of the functional roles of Group III mGluRs in a number of pathological conditions, such as epilepsy, anxiety, neurodegenerative diseases, and chronic pain.
This Research Topic will address the most recent findings on mGluRs, with particular emphasis on Group III mGluRs, whose modulation of glutamatergic transmission has a great impact on synapse functioning and neural plasticity at the base of neurological and psychiatric disorders. The overlapping of neural substrates, neurotransmitters, and mechanisms of some neurological and psychiatric disorders--such as chronic pain and affective/cognitive deficits--may represent symptoms of the same disease more than co-morbidities, due to a cause-effect relationship.
Keywords: Central nervous system, metabotropic glutamate receptors, chronic pain, pain-related emotional disorders, allosteric modulators
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.