About this Research Topic
Inhibitory glycine receptors ligand-gated ion channels with known roles in startle disease/hyperekplexia (GlyR α1), cortical neuronal migration and autism spectrum disorder (GlyR α2), and inflammatory pain sensitization and rhythmic breathing (GlyR α3). However, recent studies have revealed that GlyRs have many additional roles – for example, in the risk of panic disorder, retinal and auditory function, regulating ethanol consumption, cortical neuronal migration and circuit formation, as well as involvement in long-term potentiation and object recognition memory. There is also significant interest in GlyR α3 as a target for novel analgesics. We encourage original research or methods papers, reviews, commentaries, or perspectives that highlight new biological and therapeutic roles of glycine receptors, utilising molecular, cellular, high-throughput drug screening, electrophysiology or model organism approaches.
Keywords: glycine, glycine receptors, autism, startle disease, neuronal migration, inflammatory pain, rhythmic breathing, panic disorder, retina, hearing, alcohol, learning and memory, molecular biology, neuroscience, zebrafish, mouse, model organism, electrophysiology