Research Topic

Metabolic Changes after Kidney Transplantation

About this Research Topic

Kidney transplantation significantly mitigates the consequences of advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) and advances have been made in the past several decades. Kidney transplantation has resulted in improved survival of CKD patients and improved their quality of life. In addition, with the advanced knowledge in the field of transplantation especially effective immunosuppressive medications, a short-term renal allograft outcome has been dramatically improved. However, patients are still faced with an unfavorable long-term renal allograft outcomes and patient survival remains affected by the development and progression of metabolic and cardiovascular co-morbidities.

After successful kidney transplantation, several electrolyte and metabolic disturbances are corrected; however, some of these may remain even after improved renal function. This may explain the poor long-term renal allograft outcomes and the cardiovascular risks that kidney transplant recipients convey after successful kidney transplantation. Moreover, the development of various metabolic diseases that affect renal allograft and patient outcomes commonly occur such as new-onset diabetes, hypertension, or obesity. Since kidney transplantation involve in the interplay between immunological and non-immunological factors and these can create a complex metabolic consequence, understanding the alteration of metabolism after kidney transplantation can lead to the knowledge and practical aspects for the care of kidney transplant recipients and ultimately improve long-term renal allograft and patient outcomes.

In this research topic, we will gather the information regarding the change in metabolic and related topics after kidney transplantation to extend the information and the current evidence with the hope to stimulate further research in the field of metabolic disorders after kidney transplantation. We welcome original research or review articles in the following topics but not limited to:

• Change in metabolism and energy after kidney transplantation
• Diabetes mellitus, hypertension, lipid disorders after kidney transplantation
• Diet and nutrition after kidney transplantation
• Obesity and weight change after kidney transplantation
• Chronic kidney disease-Mineral Bone disorders after kidney transplantation
• Effects of immunosuppression on metabolism after kidney transplantation

We welcome manuscripts that discuss themes and questions that relate to metabolism, nutrition and factors that contribute to cardiovascular morbidity and mortality after kidney transplantation. The series of articles will allow the reader to better understand a broad spectrum of physiology and pathophysiology that influences the development of disease, include the nutritional requirements after transplantation, the determinants of energy expenditure and the influence of transplantation on the metabolism of patients, the development of hypertension and bone and mineral metabolic disorders that contribute to cardiovascular disease, among others.

Our goal is to curate a series of articles that will provide researchers and clinicians with the knowledge base they can use to better understand the issues surrounding metabolic and nutritional disorders after kidney transplantation, which will hopefully improve patient care and treatment outcomes.


Keywords: kidney, kidney transplantation, metabolic changes, renal function


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Kidney transplantation significantly mitigates the consequences of advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) and advances have been made in the past several decades. Kidney transplantation has resulted in improved survival of CKD patients and improved their quality of life. In addition, with the advanced knowledge in the field of transplantation especially effective immunosuppressive medications, a short-term renal allograft outcome has been dramatically improved. However, patients are still faced with an unfavorable long-term renal allograft outcomes and patient survival remains affected by the development and progression of metabolic and cardiovascular co-morbidities.

After successful kidney transplantation, several electrolyte and metabolic disturbances are corrected; however, some of these may remain even after improved renal function. This may explain the poor long-term renal allograft outcomes and the cardiovascular risks that kidney transplant recipients convey after successful kidney transplantation. Moreover, the development of various metabolic diseases that affect renal allograft and patient outcomes commonly occur such as new-onset diabetes, hypertension, or obesity. Since kidney transplantation involve in the interplay between immunological and non-immunological factors and these can create a complex metabolic consequence, understanding the alteration of metabolism after kidney transplantation can lead to the knowledge and practical aspects for the care of kidney transplant recipients and ultimately improve long-term renal allograft and patient outcomes.

In this research topic, we will gather the information regarding the change in metabolic and related topics after kidney transplantation to extend the information and the current evidence with the hope to stimulate further research in the field of metabolic disorders after kidney transplantation. We welcome original research or review articles in the following topics but not limited to:

• Change in metabolism and energy after kidney transplantation
• Diabetes mellitus, hypertension, lipid disorders after kidney transplantation
• Diet and nutrition after kidney transplantation
• Obesity and weight change after kidney transplantation
• Chronic kidney disease-Mineral Bone disorders after kidney transplantation
• Effects of immunosuppression on metabolism after kidney transplantation

We welcome manuscripts that discuss themes and questions that relate to metabolism, nutrition and factors that contribute to cardiovascular morbidity and mortality after kidney transplantation. The series of articles will allow the reader to better understand a broad spectrum of physiology and pathophysiology that influences the development of disease, include the nutritional requirements after transplantation, the determinants of energy expenditure and the influence of transplantation on the metabolism of patients, the development of hypertension and bone and mineral metabolic disorders that contribute to cardiovascular disease, among others.

Our goal is to curate a series of articles that will provide researchers and clinicians with the knowledge base they can use to better understand the issues surrounding metabolic and nutritional disorders after kidney transplantation, which will hopefully improve patient care and treatment outcomes.


Keywords: kidney, kidney transplantation, metabolic changes, renal function


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

02 April 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

02 April 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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