Research Topic

Hypocretins/Orexins

About this Research Topic

This Research Topic of Frontiers in Endocrinology is aimed to celebrate the 20th anniversary of the discovery of hypocretin/orexin. The discovery of this neuropeptide was important because it provided the identification of a subset of neurons located in the lateral hypothalamus; a region known to express other neuropeptides such as MCH, CART or neurotensin. This was a very exciting finding for two main reasons. Firstly, the lateral hypothalamus was known to play a key role in the control of neuroendocrine function, energy and metabolic homeostasis as well as reward and emotion. Moreover, despite the very precise and unique localization of their bodies, these hypocretin/orexin neurons were found to project widely in the brain, to areas such as the VTA, amygdala and the locus coeruleus.

Data gleaned since then fulfill many of the initial expectations regarding the biological relevance of the hypocretin/orexin system. One of the key findings was its characterization as one of the key mechanisms on sleep/wake regulation. This led to further developments including the use of measurements of hypocretin/orexin in CSF as a diagnostic biomarker in narcolepsy and the therapeutic use of agonists/antagonists in the treatment of narcolepsy or insomnia. Considering the presence of this neuropeptide in the hypothalamus and its involvement in the sleep/wake cycle it is unsurprising its involvement in the control of pituitary hormone secretion as well as in energy and metabolic homeostasis.

In this issue, we welcome contributions that will untangle the hypocretin/orexin system from its early identification to uncover its biological effects. We aim to provide readers with a clear view on the physiological relevance, diagnostic potential and therapeutic implications of the hypocretin/orexin system.


Keywords: Hypocretin, orexin, energy homeostasis, sleep, pituitary


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

This Research Topic of Frontiers in Endocrinology is aimed to celebrate the 20th anniversary of the discovery of hypocretin/orexin. The discovery of this neuropeptide was important because it provided the identification of a subset of neurons located in the lateral hypothalamus; a region known to express other neuropeptides such as MCH, CART or neurotensin. This was a very exciting finding for two main reasons. Firstly, the lateral hypothalamus was known to play a key role in the control of neuroendocrine function, energy and metabolic homeostasis as well as reward and emotion. Moreover, despite the very precise and unique localization of their bodies, these hypocretin/orexin neurons were found to project widely in the brain, to areas such as the VTA, amygdala and the locus coeruleus.

Data gleaned since then fulfill many of the initial expectations regarding the biological relevance of the hypocretin/orexin system. One of the key findings was its characterization as one of the key mechanisms on sleep/wake regulation. This led to further developments including the use of measurements of hypocretin/orexin in CSF as a diagnostic biomarker in narcolepsy and the therapeutic use of agonists/antagonists in the treatment of narcolepsy or insomnia. Considering the presence of this neuropeptide in the hypothalamus and its involvement in the sleep/wake cycle it is unsurprising its involvement in the control of pituitary hormone secretion as well as in energy and metabolic homeostasis.

In this issue, we welcome contributions that will untangle the hypocretin/orexin system from its early identification to uncover its biological effects. We aim to provide readers with a clear view on the physiological relevance, diagnostic potential and therapeutic implications of the hypocretin/orexin system.


Keywords: Hypocretin, orexin, energy homeostasis, sleep, pituitary


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

15 April 2018 Abstract
15 August 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

15 April 2018 Abstract
15 August 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top