Ferroptosis is a distinct form of regulated cell death that is iron-dependent and characterized by excessive lipid peroxidation. It has emerged as a critical mechanism implicated in the pathophysiology of both cancer and degenerative diseases. Advances in the field have illuminated the intricate regulation of ferroptosis through various metabolic fluxes and signaling cascades. Understanding these interactions offers promising therapeutic prospects.This Research Topic aims to investigate the complex modulation of ferroptosis with the goal of providing new therapeutic avenues and enhancing understanding of disease mechanisms. The intricate interplay between iron metabolism, oxidative stress, and lipid signaling is central to ferroptosis, influencing disease progression and resistance to therapy. This Research Topic seeks to help bridge the gap between basic science discoveries and pharmacological applications, advancing insights into ferroptosis in the following areas, but not limited to:• Exploring how targeting iron metabolism and ferroptosis regulators can overcome chemotherapy resistance.• Elucidating the mechanisms by which inhibiting ferroptosis confers protection in degenerative diseases.• Highlighting the potential of naturally derived compounds in modulating ferroptosis and related metabolic/signaling axes.• Investigating how ferroptosis interacts with inflammation and autophagy to influence disease onset, progression, and resolution.• Dissecting the contribution of major metabolic and signaling pathways to the regulation of ferroptosis sensitivity and execution.• Advancing preclinical research on targeted ferroptosis modulators towards translational studies and innovative therapeutic approaches.
Ferroptosis is a distinct form of regulated cell death that is iron-dependent and characterized by excessive lipid peroxidation. It has emerged as a critical mechanism implicated in the pathophysiology of both cancer and degenerative diseases. Advances in the field have illuminated the intricate regulation of ferroptosis through various metabolic fluxes and signaling cascades. Understanding these interactions offers promising therapeutic prospects.This Research Topic aims to investigate the complex modulation of ferroptosis with the goal of providing new therapeutic avenues and enhancing understanding of disease mechanisms. The intricate interplay between iron metabolism, oxidative stress, and lipid signaling is central to ferroptosis, influencing disease progression and resistance to therapy. This Research Topic seeks to help bridge the gap between basic science discoveries and pharmacological applications, advancing insights into ferroptosis in the following areas, but not limited to:• Exploring how targeting iron metabolism and ferroptosis regulators can overcome chemotherapy resistance.• Elucidating the mechanisms by which inhibiting ferroptosis confers protection in degenerative diseases.• Highlighting the potential of naturally derived compounds in modulating ferroptosis and related metabolic/signaling axes.• Investigating how ferroptosis interacts with inflammation and autophagy to influence disease onset, progression, and resolution.• Dissecting the contribution of major metabolic and signaling pathways to the regulation of ferroptosis sensitivity and execution.• Advancing preclinical research on targeted ferroptosis modulators towards translational studies and innovative therapeutic approaches.