About this Research Topic
However, definite causative agent(s) or single gene(s) involved in MS still remain unidentified. A deeper understanding of the immunological pathways involved goes hand in hand with further improving therapy for MS. Focal inflammation in MS, caused by de novo CNS infiltration, can be prevented effectively using peripherally-acting drugs. However, diffuse CNS intrinsic inflammation and neurodegeneration are not targeted by the current arsenal of therapeutics and patients with progressive disease courses remain difficult to treat. Generating insights into pathophysiological processes and the clinical translation of this knowledge have been a formula of success for treating inflammatory diseases. The future will show whether this will hold true for CNS-trapped inflammation and neurodegeneration and whether the ultimate goal – truly curing MS – will be possible.
This Research Topic will provide a comprehensive overview of our current understanding of the cellular and molecular mechanisms involved in Multiple Sclerosis. In addition, the current state of knowledge in imaging of MS disease will be discussed. The clinical impacts generated via insights into the pathophysiological processes underlying MS will also be presented. We welcome the submission of Original Research, Protocol, Review and Mini-Review articles that cover, but are not limited to, the following topics:
1. Role of animal models in exploring the pathophysiological processes in MS.
2. Characterization of the cellular and molecular immunological processes in MS.
3. Pathophysiological concepts of MS in relation to disease stage.
4. The importance of environmental factors in the pathophysiology of MS.
5. Updates on strategies for diagnostics (imaging) and/or treatment of MS.
6. Possible biomarkers in MS including cerebrospinal fluid.
7. MS and pregnancy.
Keywords: Multiple Sclerosis, MS
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.