About this Research Topic
Microelectrode arrays for extracellular recordings have been introduced as a non-destructive method for monitoring and manipulating the activity of electrogenic cells and of networks thereof. They are now-a-days used in various research and application fields ranging from basic neuroscience to neurotoxicity screening and neurotechnological stimulation protocols.
Progress in the MEA technology has seen recent breakthrough in the integration of several thousand recording sites, in the processing of 3-dimensional electrodes of various shapes and in developments towards transparent or flexible probes. These ongoing developments enable MEAs to be combined with many sensing modalities. Hardware developments have been accompanied by new generations of data analysis and modelling software.
Applications of the non-destructive MEA technology have a long tradition in cellular and systems neuroscience. More recently, studies of stem-cell derived neurons, assay development and micro-physiological systems are becoming very important life science applications also opening new perspectives in improving disease modelling on chip.
However, several challenges remain open in the field requesting synergetic approaches between life science and engineering science. We therefore invite contributions reporting on MEA technological developments (track 1) towards new life science applications and contributions reporting on life science applications towards personalized medicine and microphysiological sytems using state-of-the art MEAs (track 2).
Contributions to this research topic will be based largely on the abstracts submitted for the MEA Meeting 2018.
Keywords: microphysiological systems, 3D electrodes, CMOS-based MEAs, electrical imaging, electrical stimulation, stem-cell derived applications, Microelectrode array
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