About this Research Topic

Submission closed.

Adipose, or fat tissue, is the largest endocrine organ in humans and in other cases, can be the largest organ in an obese individual. Adipose tissue plays a pivotal role in age-related metabolic dysfunction and longevity. With old age, fat distribution shifts from subcutaneous to visceral fat depots, while ...

Adipose, or fat tissue, is the largest endocrine organ in humans and in other cases, can be the largest organ in an obese individual. Adipose tissue plays a pivotal role in age-related metabolic dysfunction and longevity. With old age, fat distribution shifts from subcutaneous to visceral fat depots, while triglycerides ectopically deposit on liver, muscle, bone marrow, and heart. These changes are associated to the development and progression of a variety of age-associated diseases.

Human aging is characterized by a chronic, low-grade inflammation that develops in various aging tissues. This phenomenon is termed ‘inflammaging’. Among the major source of inflammaging immunosenescence, self-debris, senescent cells, mitochondria dysfunction, microbiome, and adipose tissue can be included. Similar to inflammaging, obesity is linked to a systemic, chronic, low-grade inflammation. Adipose tissue inflammation in obesity is also termed ‘metaflammation’.

Whether inflammaging and metaflammation share common inflammatory pathways or have similar sources of inflammation, including the role of different fat depots, are important questions. It is likely there are fundamental differences between diet- versus age-dependent obesity, given the widespread immunological and physiological changes that are known to occur in old age.

This Research Topic will address the main open questions in this field such as:
• Sarcopenic obesity
• White and brown adipose tissue in aging and longevity
• Visceral and subcutaneous fat distribution in aging
• The role of perilipins in aging
• The role of diet in body composition in longevity

Keywords: Adipose tissue, Body fat, Aging, Longevity, Perilipins


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic Editors

Loading..

Topic Coordinators

Loading..

Recent Articles

Loading..

articles

Sort by:

Loading..

authors

Loading..

views

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Share on

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.