About this Research Topic
Anaphylaxis is a life-threatening acute systemic hypersensitivity reaction that is rapidly progressive and warrants urgent medical attention and prompt administration of adrenaline. Due to the ‘allergy epidemic’, western countries have seen a rising trend in incidence rates of anaphylaxis during the last 3-4 decades. Despite rapid advances in our understanding of allergy and the immunological mechanisms involved, anaphylaxis remains a clinical diagnosis for the emergency room physician.
A specialist in allergy has a pivotal role in underpinning the causative trigger and in some complex cases, dissecting the diagnosis when there are other masquerading conditions or factors involved. Studies during the last decade have highlighted (i) new biomarkers for anaphylaxis; (ii) newly described allergic conditions such as ‘red meat allergy’ that contribute to anaphylaxis risk; (iii) allergens such as chlorhexidine and patent blue dye that trigger anaphylaxis and (iv) the complexity of mast cell disorders and their impact on anaphylaxis.
In this Research Topic, we aim to bring together a faculty of international experts to present a series of ‘state of the art’ articles covering the length and breadth of anaphylaxis to provide a holistic view of this common and yet a challenging condition. We welcome the submission of Original Research, Review, Opinion and Perspective articles that cover, but are not limited to, the following sub-topics:
1. The role of innate immune cells in anaphylaxis.
2. Immunopathogenesis and pathophysiology of IgE and non-IgE mediated anaphylaxis.
3. Factors increasing the risk and severity of anaphylaxis.
4. Laboratory diagnosis of anaphylaxis and novel biomarkers.
5. Mast cell disorders and anaphylaxis.
6. Idiopathic anaphylaxis.
7. Anaphylaxis during general anesthesia.
8. Food-induced anaphylaxis: role of hidden allergens and cofactors.
9. Hymenoptera venom allergy and venom immunotherapy.
10. Management of anaphylaxis.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.