Research Topic

Role of Protein Palmitoylation in Synaptic Plasticity and Neuronal Differentiation

  • Submission closed.

About this Research Topic

Protein palmitoylation, the reversible addition of palmitic acid to proteins, is a fundamental cellular mechanism that regulates various ion channels, neurotransmitter receptors, cell adhesion molecules, scaffolding, cytoskeletal and signaling molecules. This lipid modification facilitates vesicular transport ...

Protein palmitoylation, the reversible addition of palmitic acid to proteins, is a fundamental cellular mechanism that regulates various ion channels, neurotransmitter receptors, cell adhesion molecules, scaffolding, cytoskeletal and signaling molecules. This lipid modification facilitates vesicular transport and proper subcellular localization of a modified protein to specific plasma membrane domains such as synapses. Consequently, protein palmitoylation is critical for signal transduction, assembly of a protein complex, cell adhesion, neurite outgrowth, synaptic transmission, and plasticity. In mammals, palmitoylation is mediated by 23-24 palmitoyl acyltransferases (PATs), which are also called ZDHHCs because they contain the DHCC domain, a motif composed of aspartate-histidine-histidine-cysteine. Palmitate is removed by depalmitoylation enzymes including palmitoyl thioesterases (PPT1 and 2), acyl palmitoyl transferases (APT1 and 2) and α/β Hydrolase domain-containing protein 17 (ABHD17A-C). Many of these enzymes and their substrates that regulate palmitoylation and depalmitoylation are associated with various neurological and psychiatric disorders in children and adults. Therefore, this dynamic process is potentially a promising therapeutic target.

The goal of this Research Topic is to collect papers examining the role of protein palmitoylation and depalmitoylation in synaptic plasticity as well as various other stages of neuronal differentiation including neuronal migration, axodendritic polarization, axonal guidance, synapse formation, and myelination. Topic Papers can approach these questions using combinations of genetics, physiology, biochemistry, imaging and in vivo analysis. We welcome any type of contribution including original research, review, and perspective. However, the work should emphasize the significance of palmitoylation.


Keywords: palmitoylation, Synaptic Plasticity, depalmitoylation


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top